Short-course aminoglycosides as adjunctive treatment in adults with sepsis (SAGA) - a cluster-randomized trial

DOI

This record includes meta-data from the SAGA trial, a cluster-randomized trial that was performed in the Netherlands between 2022 and 2023. Nine acute care hospitals were randomized to preferred empirical treatment of patients hospitalized with sepsis with either ceftriaxone or cefuroxime monotherapy (monotherapy arm; four hospitals) or cefuroxim combined with an aminoglycoside (combination arm; five hospitals). The primary outcome was 30-day all-cause mortality. The aim was to cross-over to the alternative intervention after one year. However, the trial was prematurely terminated to due non-compliance with the combination arm and low recruitment rates.

We are not allowed to share the data open-access due to consent restrictions. Data can be retrieved by contacting the coordinating investigator. A data transfer agreement will be required prior to sharing the data which will stipulate the terms of use.

Identifier
DOI https://doi.org/10.34894/NKVSYJ
Metadata Access https://dataverse.nl/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=doi:10.34894/NKVSYJ
Provenance
Creator van Werkhoven, Henri ORCID logo
Publisher DataverseNL
Contributor van Werkhoven, Henri
Publication Year 2024
Funding Reference ZonMw 10140021910004
Rights info:eu-repo/semantics/openAccess
OpenAccess true
Contact van Werkhoven, Henri (Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, the Netherlands)
Representation
Resource Type Clinical data; Dataset
Format text/plain; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Size 1699; 11322
Version 1.0
Discipline Life Sciences; Medicine