Replication Data for: Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties

DOI

This dataset contains the analytical data of 20 amphipathic, tetrasubstituted hydantoin derivatives and derivatives of four additional heterocycles, as wells as all the synthetic intermediates. The analytical data includes NMR raw data and HRMS, IR and SFC data as PDF files.

All amphipathic compounds were constructed to be mimics of antimicrobial peptides (AMPs) and were tested for their antimicrobial activity in the study "Investigation of Tetrasubstituted Heterocycles Reveals Hydantoins as a Promising Scaffold for Development of Novel Antimicrobials with Membranolytic Properties". The structure of all compounds can be found in the data files.

MassLynx, V4.1

LTQ Tune Plus, V2.5.5 SP2

Qual Browser Thermo Xcalibur, 2.1.0 SP1.1160

Icon NMR for TopSpin 3.2, 4.7.6 Build 22

Thermo Scientific SII for Xcalibur, 1.6.060983

Thermo Scientific FreeStyle, 1.8 SP2

Thermo Scientific Xcalibur, 4.4.16.14

Identifier
DOI https://doi.org/10.18710/A6AJN4
Related Identifier IsCitedBy https://doi.org/10.1016/j.ejmech.2023.115147
Metadata Access https://dataverse.no/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=doi:10.18710/A6AJN4
Provenance
Creator Langer, Manuel Karl ORCID logo; Bayer, Annette (ORCID: 0000-0003-3481-200X)
Publisher DataverseNO
Contributor Langer, Manuel Karl; UiT The Arctic University of Norway; Johansen, Jostein; Bayer, Annette
Publication Year 2022
Funding Reference UiT The Arctic University of Norway ; UiT The Arctic University of Norway 2017/6770
Rights CC0 1.0; info:eu-repo/semantics/openAccess; http://creativecommons.org/publicdomain/zero/1.0
OpenAccess true
Contact Langer, Manuel Karl (UiT The Arctic University of Norway)
Representation
Resource Type Analytical data; Dataset
Format text/plain; application/pdf; text/comma-separated-values; text/csv; application/zip
Size 14372; 488279; 121505; 1824; 4185; 95885; 69786348
Version 1.2
Discipline Chemistry; Life Sciences; Medicine; Natural Sciences
Spatial Coverage Tromsø