Digital innovations make it possible to work anywhere and anytime using any kind of device. Given these evolutions, availability norms are emerging at work referring to the shared beliefs and expectations among coworkers to be constantly available for work-related communication, during as well as after regular work hours. Relying on the Job-Demands Resources Model, this study aims to investigate the relationship between these availability norms and burnout symptoms. We first of all study to what extent availability norms are associated with heightened burnout symptoms. Secondly, we explore how both telepressure, as a job demand, and autonomy, as a job resource, could offer distinct and relevant explanations for the role these availability norms play in experiencing burnout symptoms. We collected data through a survey study with 229 professionally active adults. The findings indicated that indeed availability norms are significantly associated with more burnout symptoms and that both heightened telepressure and reduced autonomy offered a relevant explanation for this. This study contributes to theory and practice as we offer insight into how and why social availability norms at work could be detrimental for the occupational health of employees, which can be taken into account when setting up rules and regulations at work.