Adsorption of nanodics (stabilised by sytrene-maleic anhydride derived copolymers) at the solid liquid interface

DOI

Nanodiscs are self-assembled structures that consist of a bilayer of phospholipids controlled in diameter by a polymer or protein belt. We have already shown that such discs stabilised by the negatively charged poly (styrene-alt-maleic acid) (PSMA) will adsorb at the silicon-water interface when a lipid monolayer is present, but not on the bare silicon surface. Here we propose to repeat these measurements using a new polymer to stabilise the discs. This polymer, poly (styrene-co-maleimide) (PSMI) which is positively charged also forms discs, but in a different pH range to PSMA. This change is expected to modify the behaviour of adsorption, particularly on the bare silicon substrate and also allows the potential to remove the polymer after disc adsorption by simply modifying the pH and so destabilising the discs. This may offer a new method of making floating bilayers.

Identifier
DOI https://doi.org/10.5286/ISIS.E.61784094
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/61784094
Provenance
Creator Dr Thomas Arnold; Dr Stephen Hall; Ms Cecilia Tognoloni; Dr Rob Barker; Professor Karen Edler; Dr John Webster
Publisher ISIS Neutron and Muon Source
Publication Year 2018
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2015-06-18T08:00:00Z
Temporal Coverage End 2015-06-22T08:06:08Z