Gestational Diabetes Mellitus represents a major public health concern due to adverse maternal post-partum and long-term outcome. Current strategies to manage GDM fail to reduce the maternal risk to develop later impaired glucose tolerance and type 2 diabetes . In a rodent model of diet-induced Gestational Diabetes Mellitus without obesity, we explored the perinatal metabolic adaptations in dams with gestational IGT followed by either persistent or resolved post-partum impaired glucose tolerance. Female Sprague-Dawley rats were fed a High-Fat High-Sucrose or a Chow diet, one week before mating and throughout gestation. Following parturition, High-Fat High-Sucrose dams were randomized to two subgroups: one switched to Chow diet and the other one maintained on High-Fat High-Sucrose diet throughout lactation. Oral glucose tolerance tests were performed at Gestation-days G12 and G18, Lactation-days L12 and L18. Plasma metabolome-lipidome were characterized at G12 and L12. These oral glucose tolerance tests-raw data and metabolomics/lipidomics raw data are synthetized in this dataset

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