Replication Data for: The BCG-Corona randomized placebo-controlled trial in Dutch healthcare workers

DOI

This record includes meta-data from the BCG-Corona trial, a double-blind, placebo-controlled randomized trial comparing BCG to placebo vaccination to prevent unplanned absenteeism and COVID-19-related endpoints in healthcare workers in nine Dutch hospitals. Healthcare workers were randomized to BCG or placebo vaccination (1:1) in March and April 2020 and followed for one year. They reported daily symptoms, SARS-CoV-2 test results, and healthcare seeking behavior via a smartphone application, and donated blood for SARS-CoV-2 serology at two timepoints. BCG vaccination did not reduce unplanned absenteeism, SARS-CoV-2 infections, or SARS-CoV-2 infection duration or severity. Nasopharyngeal rest materials after SARS-CoV-2 testing were stored in two of the nine hospitals and used for 16S microbiome sequencing and viral panel testing. Those results are pending.

Identifier
DOI https://doi.org/10.34894/SCEZSB
Related Identifier IsCitedBy https://doi.org/10.1016/j.cmi.2022.04.009
Related Identifier IsCitedBy https://doi.org/10.1128/mbio.00356-23
Related Identifier IsCitedBy https://doi.org/10.3390/vaccines12060691
Metadata Access https://dataverse.nl/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=doi:10.34894/SCEZSB
Provenance
Creator Janneke H.H.M. van de Wijgert ORCID logo; Marc J.M. Bonten
Publisher DataverseNL
Contributor Julius Center for Health Sciences and Primary Care; Janneke H.H.M. van de Wijgert
Publication Year 2024
Funding Reference ZonMw 10430012010026
Rights info:eu-repo/semantics/openAccess
OpenAccess true
Contact Julius Center for Health Sciences and Primary Care (UMC Utrecht); Janneke H.H.M. van de Wijgert (UMC Utrecht)
Representation
Resource Type Clinical data; Dataset
Format application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document; text/plain
Size 273941; 876286; 344715; 22742; 667006; 1454
Version 1.0
Discipline Life Sciences; Medicine