Dynamics of phospholipid membranesaltered by fragments of the Alzheimer’s disease peptide amyloid-beta

DOI

The peptide Amyloid-ß (Aß is the main constituent of senile plaques and is a pathological hallmark in Alzheimers disease. Recently, we have investigated how the fragment Aß(25-35) and Aß(22-40) influence the dynamics in phospholipid membranes [1,2]. Most important, we could demonstrate, that the insertion of Aß fragments into DMPC/DMPS membranes increases the lateral diffusion velocity, especially in the liquid-crystalline phase. This phase is the biologically most relevant one. The published results where obtained on the time-of-flight spectrometer NEAT with an energy-resolution 93 µeV. Here, we like to confirm and extend these results with a better energy-resolution of approx. 1 and 15 µeV.

Identifier
DOI https://doi.org/10.5291/ILL-DATA.8-04-663
Metadata Access https://data.ill.fr/openaire/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=10.5291/ILL-DATA.8-04-663
Provenance
Creator Karastaneva, Hristina; Ollivier, Jacques; Barrett, Matthew; Dencher, Norbert; Hauss, Thomas; Seydel, Tilo
Publisher Institut Laue-Langevin
Publication Year 2013
Rights OpenAccess; info:eu-repo/semantics/openAccess
OpenAccess true
Representation
Resource Type Dataset
Size 23 GB
Version 1
Discipline Particles, Nuclei and Fields