We collected transcriptome data from the same individual of the cold water coral species, Lophelia pertusa, collected in the Gulf of Mexico. The first sample (Treatment A) was taken at the time the individual came on deck of the ship. After the coral was acclimated in a tank on deck for ~4 days, a second sample (Treatment B) was taken. The third sample was taken after the coral was exposed to 22 degree Celsius water for ~ one hour (Treatment C). We exposed the coral to these conditions in order to capture a comprehensive transcriptome of an adult coral. This information will aid in future development of biomarkers for genes involved in stress response.