The δ18O, δ13C, and 87Sr/86Sr records presented here are based on the stalagmite SMT16 collected in São Mateus cave (13.67°S; 46.37°W) located in the Parque Estadual de Terra Ronca (PETER) in central Brazil. This data was presented in the publication by Della Libera et al. (2026) titled "Speleothem-based reconstruction of Holocene changes in monsoonal patterns and environmental conditions in Central Brazil". The chronology of SMT16 was based on U-Th ages, performed at the Geochronology Laboratory at the University of Minnesota (USA) and at the Institute of Global Environmental Change, Xi'an Jiaotong University (China), following the methods described in Cheng et al. (2013a). The sampling for the U-Th dating was performed by extracting ~100 mg of powdered carbonate with a dentist drill along the stalagmite growth axis, with a total of 18 U-Th ages. The final chronology was determined by calculating an age-depth model using StalAge (Scholz and Hoffmann, 2011).The δ18O and δ13C analyses were performed at the Laboratory of Stable Isotopes at the Institute of Geoscience of the University of São Paulo (LES-USP) and at the Laboratory of Geodynamic, Geochronological and Environmental Studies of the University of Brasilia (LEGGA – UnB). The notation δ in the results refers to the relative Vienna Pee Dee Belemnite (VPDB) standard with the per mil deviation, with uncertainties on the values of 0.1‰. In total, 1320 samples of powdered carbonate were collected along the stalagmite growth axis with a constant spacing of 0.3 mm between samples using a Sherline Mill device with a 0.1 mm drill bit. This dataset provides an average temporal resolution of 8 years per sample.