It is essential to comprehend how marine organisms react to various environmental stressors to predict their survival and resilience in swiftly altering marine environments. Ocean acidification, microplastic pollution, and the existence of lanthanum present significant dangers to marine ecosystems. This study investigates the genome-wide transcriptomic response of sea urchins (Arbacia lixula) to different combinations of these stressors. The transcriptomic analysis will provide valuable insights into the genetic mechanisms underlying the sea urchins' response to these complex environmental challenges. This information will help us understand their adaptability and potential vulnerabilities in the Anthropocene era.