The organohalide-respiring sulfate-reducing Desulfoluna spongiiphila DBB and Desulfoluna butyratoxydans MSL71T were isolate from marine intertidal sediment and estuarine sediment, respectively. Strain DBB and strain MSL71T respired various brominated aromatic compounds. Genome sequencing reveals both strains encode reductive dehalogenase genes, corrinoid biosynthesis genes, sulfur metabolism genes and genes for detoxification of reactive oxygen species enabling them to perform organohalide respiration in marine environments rich in sulfate and (natural) organobromine compounds.