Structural Studies of Mixed Monolayers of Sulfobetaines with Phospholipids

DOI

Sulfobetaines are zwitterionic surfactants where the headgroup charges are arranged in the opposite manner to those found in phosphotidylcholine lipid headgroups. Sulfobetaines are relatively non-toxic and are being considered for drug delivery and biomaterials applications. We therefore wish to study the interactions between model lipid membranes of DMPC with insoluble sulfobetaines. We have measured X-ray reflectivity from these systems but require neutron reflectivity data with contrast variation to be able to gain information on the details of headgroup interactions in these systems. We have synthesised novel double-tail sulfobetaine surfactants, and their corresponding single tail versions in our lab, so have both deuterated and hydrogenated surfactants available. These NR measurements will enable publication of this work, and form an initial study in ongoing work.

Identifier
DOI https://doi.org/10.5286/ISIS.E.73947224
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/73947224
Provenance
Creator Dr Stephen Hall; Miss Andi Di; Ms Cecilia Tognoloni; Dr Andrew McCluskey; Dr Oliver Hammond; Miss Naomi Elstone; Professor Karen Edler; Dr Maxmilian Skoda; Dr Thomas Arnold; Dr Naomi Elstone
Publisher ISIS Neutron and Muon Source
Publication Year 2019
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Chemistry; Natural Sciences
Temporal Coverage Begin 2016-03-20T09:00:00Z
Temporal Coverage End 2016-03-24T09:00:00Z