The Effect of Sorbate-Framework Interactions on Controlled Drug Release by Zeolites

DOI

To understand the controlled release of drug molecules from zeolite hosts, we propose to study using INS the interactions of beta-blocker atenolol with the Brønsted acid sites in potential zeolite candidates for its controlled release, H-FAU (Si/Al=5), H-FAU(Si/Al=80) and zeolite beta. The H-FAU (5) sample releases the drug over a 24 hour period, whereas the H-FAU (80) sample releases over 10 days. This is counterintuitive as the much larger number of Brønsted acid sites in H-FAU (5) should slow the molecular mobility through interactions with the sorbate. QENS experiments (RB1710135) suggest that the fundamental freedom of mobility is indeed higher in the H-FAU (5) sample, and diffraction data suggests more lattice distortion upon drug adsorption in the slower releasing H-FAU (80) sample. We aim to rationalise these observations through probing sorbate-Brønsted site interactions.

Identifier
DOI https://doi.org/10.5286/ISIS.E.90583110
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/90583110
Provenance
Creator Dr Alexander O'Malley; Dr Jeff Armstrong; Dr Paul Cox; Mr Anthony Wise
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Chemistry; Life Sciences; Medicine; Natural Sciences
Temporal Coverage Begin 2018-03-12T09:00:00Z
Temporal Coverage End 2018-03-15T09:37:44Z