We present a sedimentary record from the eastern Fram Strait, Core CAGE19-3-KH14-GPC02, retrieved at a depth of 2275 meters. This record spans the Penultimate Deglacial and the Last Interglacial period (140-90 ka). Our primary goal was to reconstruct sea ice conditions and surface ocean hydrography. The dataset includes biomarker concentrations (IP25, brassicasterol, dinosterol, sitosterol, and campesterol), PIP25 indexs, dinoflagellate cyst counts and grouped relative abundances, Ca/Ti-XRF data, magnetic susceptibility, ice-rafted detritus, stable oxygen isotopic compositions of N. pachyderma, O. umbonatus, and C. wuellerstorfi, as well as age-depth tie points for the investigated core and time interval.