Predicting Kidney Failure from Longitudinal Kidney Function Trajectory: A Comparison of Models

DOI

Minimal datasets used to train and validate models described in Predicting Kidney Failure from Longitudinal Kidney Function Trajectory: A Comparison of Models.Goal: Early prediction of chronic kidney disease (CKD) progression to end-stage kidney disease (ESKD).Study design: Prospective cohortSetting & participants: We re-used data from two CKD cohorts including patients with baseline estimated glomerular filtration rate (eGFR) >30ml/min per 1.73m2. MASTERPLAN (N=505; 55 ESKD events) was used as development dataset, and NephroTest (N=1385; 72 events) for validation.Predictors: All models included age, sex, eGFR, and albuminuria.Analytical Approach: We trained the models on the MASTERPLAN data and determined discrimination and calibration for each model at 2 years follow-up for a prediction horizon of 2 years in the NephroTest cohort. We benchmarked the predictive performance against the Kidney Failure Risk Equation (KFRE).Results: The C-statistics for the KFRE was 0.94 (95%CI 0.86 to 1.01). Performance was similar for the Cox model with time-varying eGFR (0.92 [0.84 to 0.97]), eGFR (0.95 [0.90 to 1.00]), and the joint model 0.91 [0.87 to 0.96]). The Cox model with eGFR slope showed the best calibration.For the analysis scripts please refer to the supplementary file in the publiciation.

Identifier
DOI https://doi.org/10.17026/dans-znb-th2w
Metadata Access https://lifesciences.datastations.nl/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=doi:10.17026/dans-znb-th2w
Provenance
Creator A.J.G. van den Brand
Publisher DANS Data Station Life Sciences
Contributor RU Radboud University
Publication Year 2019
Rights CC-BY-NC-4.0; info:eu-repo/semantics/openAccess; http://creativecommons.org/licenses/by-nc/4.0
OpenAccess true
Contact RU Radboud University
Representation
Resource Type Dataset
Format text/csv; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet; text/xml; text/plain; application/pdf; application/zip
Size 838; 1014; 11709; 3663; 1718; 117856; 20069; 637; 394384; 50042; 88110; 35340
Version 1.0
Discipline Agriculture, Forestry, Horticulture, Aquaculture; Agriculture, Forestry, Horticulture, Aquaculture and Veterinary Medicine; Life Sciences; Medicine; Social Sciences; Social and Behavioural Sciences; Soil Sciences