The data collection contains the recorded X-ray projections for sequential tomographic scans stored as hdf5 files (raw). Registered reconstructions are provided as netcdf4 (.nc) files. Derived from the 4D grayvalue datasets, segmentated regions of interests are provided as .nc-files each for the different segmentation routes (water in GDL/FF, membrane delamination and swelling, anode catalyst layer). The zipped folder “all non-imaging data and processing code for CO2 co-electrolysis experiment” contains the recorded electrochemical data and a snapshot of the developed processing code.