The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides [Research Data]

DOI

This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave-assisted synthesis of CSY-protected peptides, and CSY cleavage in partially folded or aggregation-prone peptides.

Identifier
DOI https://doi.org/10.11588/data/ECKCUY
Related Identifier https://doi.org/10.1039/D1CB00252J
Metadata Access https://heidata.uni-heidelberg.de/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=doi:10.11588/data/ECKCUY
Provenance
Creator Pham, Truc Lam ORCID logo; Zilke, Jennifer ORCID logo; Müller, Christine Charlotte ORCID logo; Thomas, Franziska ORCID logo
Publisher heiDATA
Contributor Thomas, Franziska
Publication Year 2022
Funding Reference Deutsche Forschungsgemeinschaft (DFG) 414261058, 2082/1–390761711 (3DMM2O) ; Fonds der Chemischen Industrie Kekulé Fellowship (T.L.P)
Rights CC BY 4.0; info:eu-repo/semantics/openAccess; http://creativecommons.org/licenses/by/4.0
OpenAccess true
Contact Thomas, Franziska (Heidelberg University, Institute of Organic Chemistry)
Representation
Resource Type Dataset
Format application/zip; application/pdf
Size 1780391; 18177; 14762819; 148227; 122805400; 61872; 143820
Version 1.1
Discipline Chemistry; Natural Sciences