The structure and formation kinetics of interfacial BslA films

DOI

BslA is a globular protein that has recently been shown to play an important role in developing the morphology and hydrophobic properties of Bacillus subtilis biofilms. A molecular understanding of the role of BslA will be valuable in efforts to disrupt biofilm formation and BslA itself could find application as an emulsion stabiliser in the food industry. In vitro, BslA quickly forms an elastic layer at the air-water interface. Very little is currently known about the structure, thickness and density of such layers. We propose to perform kinetic measurements of deuterated and undeuterated wildtype and mutant (L77K) BslA film formation at an air-null reflecting water interface and measure the thickness and surface excess of fully formed films. Further, we will determine the relative position of wildtype BslA and L77K at an air-D2O interface.

Identifier
DOI https://doi.org/10.5286/ISIS.E.54816002
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/54816002
Provenance
Creator Dr Paul Clegg; Mr Joe Forth; Miss Laura McKinley; Dr Laura Hobley; Dr Simon Titmuss; Professor Cait MacPhee; Dr Keith Bromley; Mr Ryan Morris; Dr Maxmilian Skoda; Dr Iva Manasi
Publisher ISIS Neutron and Muon Source
Publication Year 2017
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences; Physics
Temporal Coverage Begin 2014-08-16T23:00:00Z
Temporal Coverage End 2014-08-20T23:00:00Z