The dataset contains the isotope compositions of dissolved Nd and Hf together with those of particulate Nd, and the concentrations of rare earth elements and yttrium (REY) and Hf ([Hf]) in surface waters along the entire salinity gradient of the Amazon estuary, including the Pará River. Samples were obtained in April–May 2018 during RV Meteor cruise M147, which was official process study Gapr11 of the international GEOTRACES program.