This project investigates the molecular mechanisms underlying the adaptation of the economically important aquaculture species, Apostichopus japonicus, to environmental stress caused by high temperature and hypoxia. Using an integrated approach combining m6A methylation sequencing (MeRIP-seq) and transcriptomic analysis (RNA-seq), this study identifies key regulatory pathways and stress-responsive genes associated with oxidative stress, immune defense, and metabolic reprogramming. The dataset includes raw RNA sequencing data from respiratory tree tissues collected under different experimental conditions (control, hypoxia, and combined high-temperature and hypoxia). These findings provide valuable insights into epigenetic regulation and stress adaptation mechanisms in marine organisms, contributing to sustainable aquaculture practices in the face of climate change.