We investigate the role of slow and transient slip as an initial condition on earthquake-hosting faults in laboratory friction experiments, using the natural fault material retrieved from the Tohoku décollement that likely hosts both fast and slow slip. For all experiments, we measure both the velocity dependence and slip dependence of friction of a core sample from JFAST (IODP Expedition 343) Hole C0019E, core sample 17R-1, which represents the plate boundary fault zone in the Japan Trench subduction zone. All experiments were conducted at 16 MPa (effective) normal stress.