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Desregulación de la sinaptogénesis por efecto del péptido beta-amiloide sobre...
Los subobjetivos principales han sido: i) el estudio de los los mecanoreceptores en la etiología y progresión de la enfermedad de Alzheimer y de la esclerosis lateral... -
Amyloid β peptide and α-synuclein association at lipidmodel membranes
We plan to investigate the interaction between amyloid proteins and model biomembranes deposited on solid surfaces. The model membranes will be single zwitterionic and mixed... -
Dynamics of amyloid protein fibril growth using isotope-labelled SANS
This proposal aims use a novel approach whereby deuterated amyloid peptide fibrils are givenhydrogenated growing ends, and analysed using SANS. The data will enable us to... -
Early stages of amyloid aggregate formation
We will study the kinetics of the early stages of aggregate formation in protein solutions under conditions that are known to result in the formation of amyloid protein fibres...
