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Evolutionary forces shaping the nucleotide composition of organisms
These mutation accumulation lines were used in addressing mechanisms of G/C composition evolution. -
Experimental evolution of multicellularity
In this project ten independent lineages of ichthyosporean Sphaerforma arctica, were serially passaged in liquid medium and exposed to elevated gravitational force... -
Pol II pausing is a milestone on the road to complex animals
PRO-seq experiments in multiple organisms. Also, PRO-seq experiment of Nelfb and Nelfe degron mESC in serum/LIF with or without dTAG-13. Overall design: We used Precision... -
DNA methylation enables recurrent endogenisation of giant viruses in an anima...
5-methylcytosine (5mC) is a widespread silencing mechanism that controls genomic parasites. However, in many eukaryotes 5mC has gained complex roles in gene regulation beyond... -
Sphaeroforma arctica strain 3-2015 genome
The project aims to re-sequence the Sphaeroforma arctica genome. The sequenced strain (3-2015) was established from a single isolated cell. -
Tracking the origin and evolutionary dynamics of RNA editing in metazoans
Whole-genome DNA-seq and strand-specific RNA-seq on 18 species, including 14 metazoans and four unicellular eukaryotes closely related to metazoans. For each species, two to...