-
Identification_of_mutational_spectra_in_fission_yeast_DNA_repair_and_chromati...
Cells are constantly under attack by a plethora of DNA damaging agents that arise from both exogenous and endogenous sources. To deal with this threat to cell and organism... -
Experimental evolution of Saccharomyces cerevisiae
Sequencing data pertaining to the experimental evolution of yeast towards ethanol tolerance, as described in Voorderckers et al, 2015. -
Saccharomyces cerevisiae S288C Genome sequencing and assembly
Saccharomyces cerevisiae S288C, complete genome -
Aneuploidy-induced proteotoxic stress can be effectively tolerated without do...
The protein homeostasis (proteostasis) network maintains balanced protein synthesis, folding, transport and degradation within a cell. Because failure to maintain proteostasis... -
Identification of New Branch Points and Unconventional Introns in Saccharomyc...
Spliced messages constitute one-fourth of expressed mRNAs in the yeast Saccharomyces cerevisiae, and most mRNAs in metazoans. Splicing requires 5' splice site (5'SS), branch... -
GNF179 Drug Selected Yeast Strains
ABC16-Monster drug-sensitive yeast strains were selected for resistance to GNF179 -
PacBio_sequencing_of_yeast_strains
In the past we have sequenced a variety of S. cerevisiae and S. paradoxus yeast strains with both capillary and Illumina sequencing (Nature 2009) and used them for functional... -
Saccharomyces cerevisiae cdc73, tel1 cdc73, and yku80 cdc73 GCR sequencing
Sequencing gross chromosomal rearrangements in wild-type, cdc73, tel1 cdc73, and yku80 cdc73 strains. -
Experimentally-evolved Saccharomyces cerevisiae clones
Whole-genome sequencing of evolved clones after 1000 generations of laboratory evolution. Strains carry SEC53 alleles implicated in human disease. -
Trajectory_and_Uniqueness_of_Mutational_Signatures_in_Yeast_Mutators
The acquisition of mutations plays critical roles in adaptation, evolution, senescence and tumorigenesis. Massive genome sequencing has allowed extraction of specific features... -
Study of regulatory kinase genetic interaction profiles in different environm...
Pooled analysis of genotypes using molecular barcode sequencing to test the role of ~4,000 gene deletion mutants and ~12,000 pairwise interactions between all non-essential... -
Saccharomyces cerevisiae S288C Genome sequencing and assembly
The model strain Saccharomyces cerevisiae S288C was sequenced using the two up-to-date systems to investigate the advantages and limitations. Then we compared the comprehensive... -
Saccharomyces cerevisiae S288C Raw sequence reads
DMS-MaPseq analysis of TLC1, NME1 and ASH1 RNA in S. cerevisiae WT and pop mutant cells. -
Saccharomyces cerevisiae strain:S288c-BY4741 Genome sequencing
We performed a directed evolution experiment under the selective stress of an alternative carbon source on a ploidy series of 1N, 2N, and 4N Saccharomyces cerevisiae... -
2-deoxyglucose resistance in diploid Saccharomyces cerevisiae
Yeast and fast-growing human tumor cells share metabolic similarities in that both cells use fermentation of glucose for energy and both are highly sensitive to the glucose... -
Integrative transcriptomic and metabolomic analysis conjures critical pathway...
Transcriptomic analysis of yeast model of ALS expressing TDP43 wild type or TDP43 mutant (Q331K) has been carried out. The experiments have been carried out in 3 biological... -
Understanding S. Cerevisiae adaptation and trade-offs under batch culture con...
We decomposed the fitness of thousands of barcoded adaptive yeast clones into components corresponding to their growth phases within their growth cycle. -
Mutagenic_mechanisms_of_cancer_associated_DNA_polymerase_E_alleles
A single amino acid residue change in the exonuclease domain of human DNA polymerase e, P286R, is associated with the development of colorectal cancers, and has been shown to... -
Sequencing gross chromosomal rearrangements in wild-type, mms21-CH, mre11, mr...
Sequencing gross chromosomal rearrangements in wild-type, mms21-CH, mre11, mre11-H125N, mms21-CH mre11, and mms21-CH mre11-H125N strains. -
CiBER-seq dissects genetic networks by quantitative CRISPRi profiling of expr...
To realize the promise of CRISPR/Cas9-based genetics, approaches are needed to quantify a specific, molecular phenotype across genome-wide libraries of genetic perturbations. We...
