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Determining the membrane binding structure of drug-delivery polymers
This proposal seeks to investigate a class of synthetic membrane-active biopolymers which have been developed as potential drug-delivery agents. These polymers have shown pH-... -
Neutron diffraction from polyunsaturated multibilayer membranes containing a ...
Polyunsaturated fatty acids (PUFAs) are essential dietary fats that have been proposed to reduce the risk of cardiovascular and auto-immune diseases, arthritis and cancer. PUFA... -
Characterising the membrane binding interaction of plant annexin Gh1
Annexins are a ubiquitous group of membrane associated proteins found in animals, plants and fungi. They are linked to wide range of functions including phospholipid... -
The Effect of solution pH on the Interaction between poly(silicic) acid and D...
We wish to investigate the pH-dependence of the strong interfacial interaction of 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) with poly(silicic) acid at the air-water... -
Co-surfactancy of oil-soluble and water-soluble surfactants in emulsion stabi...
The structures of emulsions formed from mixed oil-soluble and water-soluble amphiphiles (respectively derivatives of polyisobutylene, PIBSA, and polyacrylamide, PAM) will be... -
Probing the effects of oxidative stress on the membrane binding of alpha-synu...
Neutron reflectometry will be used to characterise the cellular membrane binding interaction of alpha-synuclein under conditions mimicking oxidative stress. Alpha-synuclein is... -
Co-surfactancy of oil-soluble and water-soluble surfactants at the oil-water ...
A technique we have recently developed enables us to simply produce stable, homogenous and thin oil layers, using polymer surfactants, in a simple manner on water. These are... -
Mechanisms of shear stability in emulsions
High internal phase water-in-oil emulsions can be efficiently stabilised by polymer amphiphiles for a static emulsion, and also show high shear stabillity even at elevated...