10 datasets found

Definition of functional regulatory regions in the vast non-coding fractions of mammalian genomes remains a daunting challenge that underscores our limited understanding of...

We mapped DNA methylation in 580 animal species (535 vertebrates, 45 invertebrates), resulting in 2443 genome-scale, base-resolution DNA methylation profiles of primary tissue...

The connection between evolution of regulatory elements and downstream gene expression is incompletely understood in mammals. We carried out a large-scale comparison of matched...

Commonly used 16S rRNA primers miss much of the archaeal diversity present in the vertebrate gut, leaving open the question of which archaea are host associated, the...

Transcriptomic and lipidomic profiling of subcutaneous and visceral adipose tissues in 15 vertebrates

This study determines that genome skimming, shallow depth of sequencing, is capable of accurately quantifying global DNA methylation level across a range of vertebrates.

Mitochondrial heteroplasmy, the presence of more than one mtDNA variant in a cell or individual is not as uncommon as previously thought. It is mostly due to the high mutation...

Established the broadest single-nucleus RNA sequencing study to date, covering 11 representative species, including pets (cat, dog, hamster, and lizard), livestock (goat and...

Large-scale metagenome assemblies of human microbiomes have produced a huge catalogue of previously unseen genomic data, but has been applied to only a few of the >66 000...

We estimated the germline mutation rate of 68 species of vertebrates using WGS of pedigrees (i.e. at least 3 individuals mother, father, and their offspring).