5 datasets found

The genetic code of viruses is typically protected by a spherical protein container. This protein capsid is assembled from hundreds of individual proteins in a spontaneous...

Guanine-­rich DNA sequences are prone to fold into stable helical four­-stranded structures called G­quadruplexes (G4). These systems have drawn the attention of a number of...

G-quadruplexes (G4) are the focus of a number of studies in both fundamental and applied research, from cancer biology and novel therapeutics through to nanotechnology. The G4...

Acquired multidrug resistance (MDR) in pathogenic microbials is a world-wide threat to human health. Several MarR–like proteins regulate the expression of efflux pumps, which...

Human dihydroorotate dehydrogenase (DHODH) is an integral membrane protein found in mitochondria involved in the biosynthesis of pyrimidines. DHODH oxidizes dihydroorotate with...