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Single cell data
Time series data as well as time of S-phase entry and cell division for individual cells under the different experimental conditions used in the published study -
FKBP12 determines ligand-specific SMAD signaling in individual living endothe...
The BMP signaling pathway plays a pivotal role in regulating the formation and maintenance of our vascular system, employing a diverse set of ligands, receptors and cytoplasmic... -
Analysis code
R code to analyze single cell, Luminex and immunofluorescence data -
Single cell data
Time-resolved analysis of nuclear-to-cytoplasmic SMAD2 ratio in individual cells. For some datasets, data regarding motility and cell death is included as well. Data is provided... -
Single cell trajectories
This dataset has no description
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Decoding stimulus-specific regulation of promoter activity of p53 target gene...
All measurements derived from smFISH experiments as well as additional output from Bayesian inference are publicly available via the institutional repository of Technical... -
FKBP12 determines ligand-specific SMAD signaling in individual living endothe...
The BMP signaling pathway plays a pivotal role in regulating the formation and maintenance of our vascular system, employing a diverse set of ligands, receptors and cytoplasmic... -
MeCP2-driven chromatin organization controls nuclear stiffness
DNA organization on chromatin has been largely studied for its consequences in gene expression, but its contribution to the cell mechanics is often neglected despite the nucleus... -
Dynamic association of H3K36me3 with pericentromeric heterochromatin regulate...
The flexibility of the spatio-temporal genome replication program during development and disease highlights the regulatory role of plastic epigenetic mechanisms over genetic... -
TET dioxygenases localize at splicing speckles and promote RNA splicing
The dynamic regulation of RNA metabolism plays a crucial part in cellular function, with emerging evidence suggesting an important role for RNA modifications in this process.... -
Uptake of substances into living mammalian cells by microwave induced perturb...
Delivering foreign molecules and genetic material into cells is a crucial process in life sciences and biotechnology, resulting in great interest in effective cell transfection... -
Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicat...
Oxidation of the epigenetic DNA mark 5-methylcytosine by Tet dioxygenases is an established route to diversify the epigenetic information, modulate gene expression and overall... -
Replisome loading reduces chromatin motion independent of DNA synthesis
Chromatin has been shown to undergo diffusional motion, and during active gene transcription the RNA polymerase activity negatively affects chromatin motion. However, the... -
The Proteomic Composition and Organization of Constitutive Heterochromatin in...
Pericentric heterochromatin (PCH) forms spatio-temporarily distinct compartments and affects chromosome organization and stability. Albeit some of its components are known, an... -
Developmental changes in genome replication progression in pluripotent versus...
DNA replication is a fundamental process ensuring the complete and accurate maintenance of the genome each time cells divide. This is particularly relevant early in development... -
Heterochromatome wide analyses reveal MBD2 as a phase separation scaffold for...
Heterochromatin is essential for nuclear integrity, genome stability, and gene regulation. However, the mechanisms governing heterochromatin compartmentalization remain poorly... -
MeCP2-induced heterochromatin organization is driven by oligomerization-based...
Heterochromatin is the highly compacted form of chromatin with various condensation levels hallmarked by high DNA methylation. MeCP2 is mostly known as a DNA methylation reader... -
The chromatin architectural protein CTCF is critical for cell survival upon i...
CTCF is a nuclear protein initially discovered for its role in enhancer-promoter insulation. It has been shown to play a role in genome architecture and in fact its DNA binding... -
The human Timeless-Tipin complex assures the replication fork protection ahea...
The accuracy of replication is one of the most important mechanisms ensuring stability of the genome. The fork protection complex prevents premature replisome stalling and/or... -
Exposure of cells to near-infrared irradiation relaxes chromatin compaction a...
Ultraviolet A and B (UVA 320-400 nm and UVB 280-320 nm) induced cyclobutane-pyrimidine dimers (CPDs) are the most critical lesions caused by environmental sun exposure. Here we...
