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Unravelling the solution structures and stability of industrially-important a...
The glycosylation of glycoproteins is a major determinant of their stability, and glycans also affect their aggregatibility (precipitation). An understanding of this is... -
DOMAIN MOVEMENT IN CYTOCHROME P450 REDUCTASE
Cytochromes P450 play a key role in drug metabolism in man. Electrons are supplied to the cytochromes by NADPH through the flavoprotein NADPH-cytochrome P450 reductase (CPR).... -
Effect of reversing lipid head group charge on vesicular properties
Zwitterionic lipids such as phosphatidylcholine (PC) are major components of the membranes that compartmentalize organisms. Although there is a large literature on PC, cationic... -
SANS study on the aggregation behavior of aza-crown-water soluble conjugated ...
Water-soluble conjugated polymers (WSCP) are an important class of materials which have received great attention as active materials in optoelectronic devices and in biosensing.... -
Solubilisation of Drug Molecules in Nonionic Surfactant Micelles: Structural ...
This proposal aims to understand how the structure of non-ionic surfactant micelles affects the amount of fungicides solubilised. SANS is a technique unique for unravelling the... -
Solution aggregation of lipopeptides: SANS structure determination
Lipopeptide surfactants are highly effective at reducing interfacial tension. However, there is a general lack of understanding of the relationship between their molecular... -
Can SANS confirm whether dimensions from microscopy of dried gels are represe...
Characterisation of structures formed within hydrogels is an important part of understanding their properties and how they can be used in real world applications. The real space... -
Phase Separation in Organic Photovoltaic Cells
Organic photovoltaic (OPV) cells have the potential to be the basis of a renewable energy source that is inexpensive and portable. Current state-of-the-art solution-processed... -
Origin of co-nonsolvency, based on the Flory-Huggins interaction parameters o...
Co-solvency and Co-nonsolvency are two extreme phenomena in the field of polymer solution. The former is the phenomenon that a mixture of two nonsolvent forms a good solvent for... -
SANS evaluation of novel nanocolloidal drug carriers
With the beamtime requested we plan to employ small-angle neutron scattering (SANS) to study novel nanocolloidal drug carriers prepared using lipids, surfactants and... -
STRUCTURE OF THE COMPLEX BETWEEN CYTOCHROME P450 REDUCTASE AND CYTOCHROME C
Cytochromes P450 play a key role in drug metabolism in man. Electrons are supplied to the cytochromes by NADPH through the flavoprotein NADPH-cytochrome P450 reductase (CPR).... -
Constructing analogues of Gemini and oligomeric surfactants using polyamines
Gemini or oligomeric surfactants, where two or more alkyl chains and headgroups are connected via spacer groups, have interesting and potentially important properties which make... -
Understanding the properties of nucleobase functionalized nanostructures
We have recently prepared a number of new nucleobase functionalised polymers which undergo interesting and unexpected self-assembly. We hope to use SANS to explore further the...
