-
Effect of calcium ions and ionic strength on model bilayer structure
Calcium ions have been shown in a preliminary experiment to have a dramatic effect on the thickness and structure of free supported bilayer films. In this proposal we... -
Elucidating buried structures using Offspec
This proposal is a continuation proposal (previous RB 1110285) utilising the Offspec instrument and is aimed at further understanding the utility of the spin echo grazing... -
Spontaneous multilayer formation at interfaces in mixed surfactant systems
The spontaneous formation of multilayer structures at interfaces from surfactant self-assembly has until recently been rarely observed. However, surface multilayer structures... -
Interfacial properties of a lung protein after exposure to gas-phase ozone
Lung surfactant protein B, SP-B, is found at the air-water interface of the lung. A deficiency in SP-B at birth is known to be fatal. We have recently successfully studied the... -
Structural studies of thermo-responsive nanogels at the oil-water interface
Nanogels because of their three-dimensional physical structure and tunable chemical properties as well as their stimuli-responsive nature have emerged as one of the most... -
Conformational analysis of subtilin / lipid II binary antibiotic/target membr...
We propose to use neutron reflection to characterise the position and shape of subtilin/lipid II pore complexes as well as to characterise the kinetics of subtilin-lipid II and... -
Interfacial conformation of antibody and antigen binding capacity
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element... -
The analysis of Indo-Persian armour in the Wallace Collection
Our long-term aim is a detailed study of the Oriental Arms & Armour in the Wallace Collection, London, which contains nearly one thousand items and is one of the most... -
Complete data set of different hydrations levels of alpha-Lactalbumin
Zaccai et al. proposed to build up a neutron Dynamics Data Bank which would be populated with dynamical data of biological macromolecules measured with different techniques,... -
Amyloid β peptide and α-synuclein association at lipidmodel membranes
We plan to investigate the interaction between amyloid proteins and model biomembranes deposited on solid surfaces. The model membranes will be single zwitterionic and mixed... -
Understanding the decrease in adsorption of surfactants at a solid surface ab...
Previous data obtained from neutron reflection shown in Figure 1 has clearly shown that the surface excess of some surfactants when adsorbed from aqueous solution to a sapphire... -
Effects of Architecture on Polymer Diffusion
As part of a wider study we are studying the effects of polymer architecture between cyclic and linear polymers. From ATR-FTIR measurements we observe clear differences between... -
Effect of Temperature on the Transbilayer Structure of a Model Erythrocyre Me...
In recent years, it has become understood that rather than being homogenous mixtures, biomembranes show a complex phase behaviour, with regions of uniform phases, and others... -
Cationic surfactants adsorbed to titanium dioxide-effect of pH and added elec...
Titanium dioxide (TiO2) is used in a wide range of applications from medical and dental implants to treatment of contaminated air and water streams. However many of the... -
Surfactant mixing at hydrophilic solid/aqueous interfaces
By applying the regular solution model (RS) to the determination of composition in a mixed surfactant layer adsorbed at a hydrophilic solid/aqueous interfaceand combining it... -
Probing membrane localisation of molecular rotors (NR)
A number of important biological processes, such as intracellular transport and signal transduction depend on the viscosity and the distribution of microdomains in cells. We... -
The Effect of the Head Group on Multilayering of Alkanoic Alkyl Ester Sulphon...
We have shown that under certain conditions multilayer adsorption of surfactants occurs at the air-water interface. in which case the system becomes a powerful wetting agent (it... -
Multilayering of Methyl Ester Sulphonates at the Air-Aqueous Interface: Effec...
Surfactants usually form a single layer of molecules at the surface of water. We have shown that under certain conditions more than one layer may form. When this happens the... -
Elucidating molecular mechanism of membrane disruption by designed α-hel...
We have previously shown that peptides such as G(IIKK)4I-NH2 (G4) can kill bacteria and inhibit cancer cell growth whilst remaining benign to mammalian host cells. We have also... -
Disorder in substituted beta-tricalcium phosphate for waste immobilisation
We have a long established interest in the materials used for the immobilisation of nuclear waste from the domestic power industry and legacy waste from various defence...