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Structure of Colloidal Crystals Near a Solid Surface
The structure of colloidal crystals (dispersions of particles that spontaneously order in a regular array) is known to be influenced by solid boundaries. However there are few... -
Study of Small molecule effects on AB interactions with model lipid layer by ...
Neutron reflectometery will be used to provide the vital information about the interaction/conformation of the organophosphonate compound on the lipid structure in the... -
Effect of calcium ions and ionic strength on model bilayer structure
Calcium ions have been shown in a preliminary experiment to have a dramatic effect on the thickness and structure of free supported bilayer films. In this proposal we... -
Interfacial properties of a lung protein after exposure to gas-phase ozone
Lung surfactant protein B, SP-B, is found at the air-water interface of the lung. A deficiency in SP-B at birth is known to be fatal. We have recently successfully studied the... -
Ligand induced changes of the 18kDa translocator protein in a lipid bilayer
The proposed experiments will investigate conformational changes of the 18kDa translocator protein (TSPO) in a lipid bilayer using neutron reflectometry at the solid-liquid... -
Conformational analysis of subtilin / lipid II binary antibiotic/target membr...
We propose to use neutron reflection to characterise the position and shape of subtilin/lipid II pore complexes as well as to characterise the kinetics of subtilin-lipid II and... -
Interfacial conformation of antibody and antigen binding capacity
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element... -
Amyloid β peptide and α-synuclein association at lipidmodel membranes
We plan to investigate the interaction between amyloid proteins and model biomembranes deposited on solid surfaces. The model membranes will be single zwitterionic and mixed... -
Understanding the decrease in adsorption of surfactants at a solid surface ab...
Previous data obtained from neutron reflection shown in Figure 1 has clearly shown that the surface excess of some surfactants when adsorbed from aqueous solution to a sapphire... -
Effect of Temperature on the Transbilayer Structure of a Model Erythrocyre Me...
In recent years, it has become understood that rather than being homogenous mixtures, biomembranes show a complex phase behaviour, with regions of uniform phases, and others... -
In situ study of destruction of a denatured surface protein by protease (Savi...
New detergents will increasingly rely on sustainable products and the use of enzymes will become ever more important. However, the process of destruction of stains (often... -
Surfactant mixing at hydrophilic solid/aqueous interfaces
By applying the regular solution model (RS) to the determination of composition in a mixed surfactant layer adsorbed at a hydrophilic solid/aqueous interfaceand combining it... -
Probing membrane localisation of molecular rotors (NR)
A number of important biological processes, such as intracellular transport and signal transduction depend on the viscosity and the distribution of microdomains in cells. We... -
Interfacial layer structure of designed linear lipopeptides
Lipopeptide surfactants are a group of interesting biosurfactants due to their natural origin and their high effectiveness at reducing interfacial tension. However, there is a... -
Enzyme-catalysed templating of biosilica
Summary. Silicatein in marine sponges catalyses the condensation of silica but the mechanism of layer-by-layer growth of the silica spicule is unknown since sufficient... -
Adsorption Kinetics and Structure of Silicatein Mediated Silica Films
The fabrication of composite coatings based on silica with well defined physical properties represents a promising new approach to fine-tune mechanical, optical, electronic, and... -
Co-surfactancy of oil-soluble and water-soluble surfactants at the oil-water ...
A technique we have recently developed enables us to simply produce stable, homogenous and thin oil layers, using polymer surfactants, in a simple manner on water. These are... -
pH-Responsive Polyelectrolyte Brushes Studied by Neutron Reflectivity and in ...
pH-responsive polymer brushes comprise of long polymer chains of either a weak acid or base chemically attached to a surface. Depending upon the degree of ionisation along the... -
Interfacial conformation of antibody and antigen binding capacity
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element... -
Swelling of Single Supported Bilayers ¿ First Systematic Investigation of the...
This proposal addresses bilayer swelling experiements on floating supported bilayers (FSBs) in the presence of biological buffers. Previous work on multilamellar vesicles has...
