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The effect of dendrimer surface functionalization on the interaction with mod...
Dendrimers are a unique class of nano-structured vehicles for drug and gene delivery into intracellular targets. Their surface chemistry influences their transport across... -
Effect of membrane fluidity for novel dendrimer drug interaction and uptake m...
Bacteria growing resistant to common antibiotics is a growing problem and research in new types of medicines which do not induce resistance is therefore very important. Novel... -
Seizing Membrane Proteins - Cytochrome P450 Reductase in Nanodiscs
This proposal seeks to shed light on the functional and structural characteristics of a specific membrane protein - cytochrome P450 reductase (abb. POR) - part of the cytochrome... -
Spatially profiling internal microstructure changes during redox driven rapid...
The redox driven swelling and deswelling of conducting polymers has been termed Electronic Muscle actuation. One application of this property is as a sphincter-like valve in a... -
Understanding the insertion of antibiotic toxins into the gram negative outer...
The gram-negative bacterial membrane is of extreme medical importance. Two of its major components are lipopolysaccharides (LPS's) and integral membrane proteins. Porins are... -
Protein exchange at the solid/liquid interface
The balance of proteins adsorbed at a surface is important in a wide range of situations, e.g. implants, nanoparticles. The accepted model is that rapidly diffusing proteins... -
Tuneable Adsorption of Soft Colloids on Model Biomembrane
Understanding how nanoparticles interact with lipid bilayers will potentially have high impact on the development of new drug delivery systems, and on the investigation of their... -
The interpenetration of two poly(ethylene oxide) polymer brushes under confin...
Coating two surfaces with polymer brushes has been shown on many occasions to reduce friction by orders of magnitude. These ultra-low frictions are believed to stem from be the... -
Confinement and Liquid Crystal Films
Liquid crystals (LCs) are known to act as good lubricants, however, the reason for this remains unclear. One contributing factor is thought to be the formation of ordered layers... -
Polymer-surfactant films containing glucose sensors
This proposal continues our research on mesostructured surfactant templated polymer films that form spontaneously at the air-water interface. Our recent research has shown it is... -
Antibiotic Interactions with models of the Gram negative bacterial outer memb...
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