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A search for the muoniated hydroxyl radical, OMu
The elusive OMu radical is believed to be formed by muonium reaction with nitrous oxide but has never been directly observed. It would be invisible to transverse-field muon spin... -
Application of direct inversion to magnetic contrast datasets.
We have developed an experimental approach using a buried magnetic layer to provide contrast in systems consisting of complex biomolecular layers tethered to gold surfaces. This... -
Contrast variation studies of novel binary polypeptide gels
Low molecular weight gelators (LMWG) form hydrogels via self-assembly in water under specific conditions to form long, fibrillar structures. Non-covalent forces interactions... -
Structural changes in electron transfer proteins used in biophotovoltaic cell...
This proposal seeks to gain an understanding of the adsorption and desorption behaviour of a redox membrane protein, cytochrome c, in electrochemical cells using different anode... -
Neutron Reflectivity Study of Protein Adsorption onto Cell Membrane-inspired ...
We grafted 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer brush from the silicon wafer surface through Cu (0) mediated controlled radical polymerization (CuCRP) to mimic... -
Self-assembling behaviour of N-acyl amino acid-based surfactants
N-acyl amino acids are surfactants with attractive applications in different technological fields. They are referred to as mild surfactants because they are commonly considered... -
Conformational analysis of subtilin / lipid II binary antibiotic/target membr...
Antibiotic resistance is pathogenic bacteria is a major clinical problem. Resistance to all antibiotiotic classes, currentl yin clinical use, has been reported. By contrast, the... -
Neutron reflectivity studies of the interaction of Amphotericin B with biomim...
Bio-surfactants that can be harvested from micro-organisms are of particular interest, because these can potentially be harvested in high yield and at low cost. In this category... -
Calcium mediated interaction between siRNA and phospholipid bilayers: the eff...
The main objective of the present study is to gain an understanding of the nature of the interaction of ¿phospholipid membranes¿ with small, interfering RNA (siRNA) in the... -
Characterisation of Precious Metal Hydrous Oxide and Hydroxide Compounds
Approved proposal under the ICRD Scheme Proposal ICRD0003 -
Interaction of polypeptide with surfactant on the surface of water
This proposal constitutes part of our ongoing study towards understanding the adsorption of collagen based polypeptide and its interaction with ionic surfactants at the... -
Interfacial layer structure of lipopeptides adsorbed at the air/water interface
Lipopeptide surfactants are a group of interesting biosurfactants due to their natural origin and their high effectiveness at reducing interfacial tension. However, there is a... -
Adsorption of bioengineered antibodies at the oil/water interface
Following our previous study of adsorption of Fc, Fab and the constituent mAb COE-3, we continue to explore how two bioengineered mAbs adsorb at the oil/water interface by... -
Revealing the Structure behind the Synergistic Phase Behavior of the Ternary ...
The aim of this collaborative proposal is to unravel micro- and nano-structures underlying unusually high solution viscosities from mixed surfactant systems. SANS is a unique... -
Solution structures of the immunologically important proteins IgG and C3b
IgG antibody represents one-third of new drugs currently in development. We will unravel the solution structures of the Fab and Fc fragments within IgG. Following our earlier... -
Ca-ions at PS-containing biomimetic lipid layers: Interfacial water
Lipid membranes provide a sensitive platform for a variety of biological functions, and membrane lipid distributions are carefully regulated. In this project we plan to study... -
Surface adsorption in hydrophobin and hydrophobin / surfactant mixtures
Hydrophobins are secreted fungal proteins and are small lipopeptide biosurfactants. They are strongly surface active and self-assemble at interfaces. Their unique film forming... -
Structural characterization of a series of polymer-protein conjugates for chr...
Polymer-protein conjugates have been designed to deliver an appropriate target growth factor to promote a more rapid healing of chronic wounds, an incredibly important area for... -
Introducing the O-antigen into Bacterial Outer Membrane Models
The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the... -
Solution aggregation of short peptide surfactants
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation....
