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The solution structure of the OmpF¿Colicin N complex in neutral detergent by ...
Gram negative bacteria cause a wide range of diseases. Colicins are protein toxins capable of penetrating the outer membrane barrier and killing the bacteria. Thus they... -
W/CO2 nanodispersions as an energy-saving nanoreactor separable by pressure a...
Recent studies implied an unusual headgroup (HG)-free, fluorocarbon (FC) surfactant Nohead FC6-HC4 to form stable, W/CO2 nanodispersions (W/C NDs). With the unusual surfactant... -
Applying self-assembly in deep eutectic solvents to templated ionothermal syn...
Deep Eutectic Solvents (DES) are a subclass of room temperature ionic liquids (ILs). They are mixtures of an organic salt with a hydrogen bond donor that form strong... -
CATIONIC POLYMERS AS POTENTIAL GENE DELIVERY AGENTS: EVALUATION OF CONFORMATI...
Bio-responsive polymers hold great promise as delivery vehicles for drugs, peptides and proteins as their chemistry can be tuned to effect a change in physico-chemical... -
DNA unwinding mechanism of the archaeal helicase PabMCM in its octameric conf...
The process of cell division requires precise duplication of the genetic material. The separation of the two strands of DNA and the progression of the replisome are driven by... -
Encapsulation of hydrophobic species in mixed micelles in polymer solutions
This proposal continues our investigations into film-forming polyelectrolyte-surfactant solutions. We have found that mixed micelle systems offer greater control over micelle... -
Controlled Assembly of Cationic Polythiophene-Surfactant Complexes
We intend to study the phase behaviour of 2 cationic polythiophenes, P3MAHT and P3ImiHT, in the presence of the perfluorinated surfactant potassium... -
Polymer layer structure in stabilised metal nanoparticles for heterogenous ca...
The controlled synthesis of precious metal nanoparticles of the appriopriate chemical composition, optimised size and morphology for use in catalysis is an ongoing experimental... -
Centrifugal Force Spun Fibres
Centrifugal force spinning is a technique that has recently come into light as an easy route to producing large quantities of nano- to micro- scale polymer fibres in a short... -
A SANS Study on the Influence of Shear on Peptide Fibrillisation
Time-resolved SANS will be performed to investigate the effect of shear on the fibrillisation of insulin following denaturation. The rheological response will be measured... -
Interaction of a pH-sensitive Polymer with a Model Lipid Membrane in the Form...
This SANS experiment was proposed by 4 PhD students from 3 different institutions in a Marie-Curie Training Network. They are all in the second year of their PhD and their... -
Phase separation of poly(ethylene glycol) and of poly(propylene glycol) in mi...
Phase behaviour studies have identified hydrogen bonding as a key aspect in polymer solubility in fluorinated liquids, both in terms of solute-solvent and solute-solute... -
Conformational behaviour of amphiphilic polymethacrylate-poly(acrylic acid) c...
We shall use SANS to investigate the conformational behaviour of a range of amphiphilic copolymers with varying architectures: graft, hyperbranched block, hyperbranched random,... -
SANS contrast measurements on important protein/DNA interactions from RCaH
This proposal is to perform SANS contrast measurements on three protein/DNA interactions currently worked on at the Research Complex at Harwell. This is part of an ongoing... -
Mixed micelles of nonionic and metallosurfactants (P123/CTAF) as porogens of ...
Non-ionic/metallosurfactant (P123/CTAF) mixed micelles are used as templates for the hydrothermal synthesis of mesoporous ferrisilicate materials. It was hypothesized that... -
Static and dynamic structure of oil/water microemulsions to improve enhanced ...
After initial and secondary oil recovery up to 50% of the oil can be left behind in the reservoir. Various enhanced oil recovery (EOR) techniques can be applied to improve the... -
Temperature driven self-assembly of amphiphilic block copolymers in water.
Amphiphilic copolymers with perfluoroalkyl blocks provide self-assembled nanostructures, in water, via the association and/or self-folding of the copolymer chains. This feature... -
Micellization in mixtures of surfactants used in fire-fighting foams
The aim is to probe the mixed micellar compositions of three common industrial fluorotelomer surfactants used in fire-fighting foam formulations (Figure 1) using contrast... -
SANS evaluation of novel nanocolloidal drug carriers
With the beamtime requested we plan to employ small-angle neutron scattering (SANS) to study novel nanocolloidal drug carriers prepared using lipids, surfactants and... -
The effect of particles on the structure of mucin ¿understanding the challeng...
Progress in the development of nano-sized hybrid therapeutics and nano-sized drug delivery systems - "nanomedicines" - over the last decade has been remarkable. One key...
