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Using the nano discs approach at surfaces to determine the relation between s...
Membrane bound proteins continue to be to date the most elusive molecules in nature, since they are only functional in the lipid bilayer. We have developed a method to study... -
Understanding the insertion of antibiotic toxins into the gram negative outer...
The gram-negative bacterial membrane is of extreme medical importance. Two of its major components are lipopolysaccharides (LPS's) and integral membrane proteins. Porins are... -
Oxidation of thin film at the air-water interface of cloud droplets using REA...
The Earth's climate is strongly influenced by clouds. The oxidative processing of pollutants in clouds affects droplet size and optical properties, important effects. Common... -
Investigating the surface structure and composition of binary ionic liquid mi...
The structure of ionic liquid (IL)-gas interfaces is currently a hot topic in the field and our understanding of pure ILs is improving. However, very little is known about the... -
Part B: Binding behaviour of PAMAMs G5 and G4.5 to zwitterionic and anionic l...
Polymers are commonly used in drug delivery to create dosage forms that enable delivery of the active ingredient to the site of action within the body. Towards controlled drug... -
Spatially profiling internal microstructure changes during redox driven rapid...
The redox driven swelling and deswelling of conducting polymers has been termed Electronic Muscle actuation. One application of this property is as a sphincter-like valve in a... -
Dynamical process of helical-biskyrmion transformation of hexagonal magnet Mn...
Magnetic skyrmions are vortex-like, magnetic-spin objects that were lately discovered in bulk chiral magnetic materials. Recently, we discovered super stable magnetic... -
Seizing Membrane Proteins - Cytochrome P450 Reductase in Nanodiscs
This proposal seeks to shed light on the functional and structural characteristics of a specific membrane protein - cytochrome P450 reductase (abb. POR) - part of the cytochrome... -
Simltaneous dielectric spectroscopy and neutron diffraction
We have constructed a novel microwave frequency resonator that can sit within the GEM and POLARIS diffractometers and will allow us to simultaneously collect diffraction and... -
Biosurfactant conventional surfactant mixing. Where nature does it better ?
Biosurfactants are becoming more commonplace in pharmaceuticals, vaccines and other forms of medicines. With the biobased economy growing substantially and pressure to reduce... -
Clarifying the role of acid and base dopants in the hydrogen-ordering phase t...
Using ISIS facilities, our team has discovered three new phases of ice: ices XIII, XIV and XV. These phases form in the presence of small amounts of hydrochloric acid. Yet, the... -
Surfactant adsorption onto model surfaces
In the context of home and personal care products, studying surfactant and mixed surfactant adsorption ion model solid surfaces, which mimic real surfaces such as fabrics, hair... -
Neutron diffraction study of crystal structures and magnetism in PbRuO3 perov...
We have synthesised the ill characterised perovskite PbRuO3 at high pressure and temperature. Synchrotron powder x-ray diffraction shows the room temperature structure to be... -
Adsorption of cationic surfactants to Al2O3
A recent experiment has provided clear evidence for a large maximum in the adsorption just below the critical micelle concentration of the surfactant hexadecyl trimethyl... -
Investigating the structure of the pulmonary lung surfactant at the air-water...
The lung surfactant is a film coating the alveolus of the lung. We want to characterize the structure of this film at the air-water interface at a molecular level. This will... -
Effect of membrane fluidity for novel dendrimer drug interaction and uptake m...
Bacteria growing resistant to common antibiotics is a growing problem and research in new types of medicines which do not induce resistance is therefore very important. Novel... -
The effect of dendrimer surface functionalization on the interaction with mod...
Dendrimers are a unique class of nano-structured vehicles for drug and gene delivery into intracellular targets. Their surface chemistry influences their transport across... -
Spin-Driven Multiferroics CdMn7O12 and SrMn7O12
We propose to perform neutron diffraction experiments on powder samples of possible spin-induced multiferroic materials, 114CdMn7O12 and SrMn7O12, at ambient pressure and low... -
The search for long range exchange interactions in the S=1 square lattice ant...
Exchange interactions in insulators can be understood in terms of the Andersen exchange picture in which the Hamiltonian has two contributions: (i) a kinetic term characterized... -
Outer membrane mimics using novel thiol-PC
We have recently shown that dense monolayers of PC can be assembled on gold surfaces using a new omega thiol PC from Avanti. This has two advantages over our previous methods....