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Magnetic contrast reflectometry to resolve transmembrane potential effects on...
The division of bacteria is controlled by the binding of proteins to the inner of the two lipid bilayer membranes that separates the inside of the cell from the outside world.... -
Antimicrobial Peptide Binding & Rearrangement in Model Membranes ¿ Building a...
Antimicrobial peptides (AMPs) are attractive drug candidates because of their selectivity and speed of action against bacteria. We have developed a novel approach to delivering... -
Mimicking Pathogens : Floating Gram Negative Bacterial Membranes Containing t...
Recently we have been able to show two advances in the creation of realistic models of the Gram negative bacterial outer surface for use in biophysical and structural studies.... -
Structural characterisation of vaccine-adjuvant interactions using neutron re...
This dataset has no description
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Structural modelling of meibomian lipid films
Meibomian lipids spread on the surface of tears to enable formation of a stable film. Our data show that meibum forms duplex films that have physical properties not emulated by... -
Floating Lipid Bilayers Created by Vesicle Fusion
'Floating LSupported Bilayers' (FSB's) have become the 'standard' systems used for studying membrane systems using reflectivity at ISIS and other facilities. They are reliable,... -
The influence of transmembrane potential on the orientation of antimicrobial ...
Natural antimicrobials are of great interest, since they are antibiotics that act on the biological membrane, and it is believed that this makes it far more difficult for... -
Molecular architecture of monolayers formed by novel sterol-modified phosphol...
A family of sterol-modified glycerophospholipids (SML) have been synthesized in which the sn-1 or sn-2 position is covalently attached to cholesterol and the alternative... -
Comparing the assembly of LPS into model Outer Membranes by Langmuir-Blodgett...
We have recently created and published a model of the Gram negative bacterial Outer membrane (OM) which recreates many aspects of its behaviour and will improve our ability to... -
Manipulating surface adsorption of SLES surfactants using temperature
Although surfactant detergency is well understood above 30 C, actions of surfactants below 30 C are not well established. In the era of energy saving and environment caring, we... -
Characterisation of bioadhesive protein-PEG conjugates grafted to titanium su...
Summary: Titanium implants are surgically important and require a hydrophilic polymer coating to prevent biofouling in situ. Bioadhesive proteins can be covalently tethered to... -
Effect of calcium ions and ionic strength on model bilayer structure
Calcium ions have been shown in a preliminary experiment to have a dramatic effect on the thickness and structure of free supported bilayer films. In this proposal we... -
Conformational analysis of subtilin / lipid II binary antibiotic/target membr...
We propose to use neutron reflection to characterise the position and shape of subtilin/lipid II pore complexes as well as to characterise the kinetics of subtilin-lipid II and... -
The Mechanism and Kinetics of Lipid Flip-Flop in Floating Phosphatidylcholine...
In order to maintain their asymmetric lipid distribution, cellular membranes have a number of means to translocate lipid molecules across the bilayer. On top of the well-studied... -
Analysis of the Self-Assembled S-layer Protein SpbA on Silanised Planar Silic...
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Effect of Bilayer Asymmetry on Field-Driven Changes in Phospholipid Bilayers
Supported phospholipid bilayers have been often studied as mimics of biological cell membranes, in order to study lipid behaviour and lipid-protein interactions. These include... -
The effect of dendrimer surface functionalization on the interaction with mod...
Dendrimers are a unique class of nano-structured vehicles for drug and gene delivery into intracellular targets. Their surface chemistry influences their transport across... -
Assembling floating, very sparsely tethered, protein-lipid bilayers.
We have recently used Polref in to measure the assembly of tethered floating lipid bilayers. These are useful models of biological membranes in which a phospholipid bilayer is... -
Swelling of Single Supported Bilayers ¿ First Systematic Investigation of the...
This proposal addresses bilayer swelling experiements on floating supported bilayers (FSBs) in the presence of biological buffers. Previous work on multilamellar vesicles has... -
Examination of Free Floating Models of the Gram-Negative Bacterial Outer Memb...
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