The data presented is obtained from a study that was aimed at determining the factors associated with the immunization coverage of PCV and Rotavirus in Busolwe town council, Butaleja District in Eastern Uganda. The data was obtained in three major sections of demographic characteristics, knowledge, and attitude and perceptions of care takers of U5C on immunization. Both qualitative and quantitative types of data obtained from Primary and Secondary data sources are presented. The Primary sources included administration of questionnaires to the caretakers of U5C in communities surrounding different health centers in Butaleja district. Focus group discussions and In-depth interviews of key people such as Village Health Teams (VHTs) were also employed in generating the data. The secondary source of data was majorly the Health Management Information Systems (HMIS) records of Busolwe District Hospital and included the quarterly reports to statistically represent the immunization coverage in Butaleja district. The data includes the research questionnaires, in-depth interview guides, raw data from individual participants, the consolidated raw data from all the participants in form of microsoft coma separated values, and raw data from the secondary data sources on immunization coverage in the district.