The Effect of Framework Structure and Composition on Controlled Drug Release by Zeolites

DOI

The mobility of beta-blocker and angina/hypertension drug atenolol in zeolites FAU and BEA will be probed using QENS to understand the importance of fundamental sorbate-framework interactions on the controlled release of these promising new dosage forms. Subtle changes to the framework composition have significant effects on the measured release rates of the drug. We will measure the atenolol mobility in FAU with Si/Al ratios of 5 and 80, where (counterintuitively) the release rate is significantly higher in the former despite there being more Bronsted sites for favourable interactions (not emulated by MD simulations of mobility). We will also measure the mobility in smaller pore BEA in comparison with FAU, where simulations show slower mobility in the former correlating with the release rate. We may then gauge the importance of fundamental mobility on controlled drug release rates.

Identifier
DOI https://doi.org/10.5286/ISIS.E.86392144
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/86392144
Provenance
Creator Dr Alexander O'Malley; Dr Paul Cox; Dr Ian Silverwood; Professor Richard Catlow
Publisher ISIS Neutron and Muon Source
Publication Year 2020
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Chemistry; Life Sciences; Medicine; Natural Sciences
Temporal Coverage Begin 2017-05-23T08:00:00Z
Temporal Coverage End 2017-05-30T11:34:31Z