Fig. s1: XIC peak areas (mean ± SD) of salivary cystatins (a), histatins (b), bPRPs (c) analysed in the acid-soluble fraction of resting whole saliva (1), stimulated whole saliva (2), parotid saliva (3) and submandibular-sublingual saliva (4) of BMS patients (in grey) and healthy controls (in black). Only Significant p values are indicated. Fig. s2: XIC peak areas (mean ± SD) of statherin and its proteoforms (a), P-B peptide (b), cystatin C and B (c), α-defensins (d) and Ps-1 and II-2 (e) analysed in the acid-soluble fraction of resting whole saliva (1), stimulated whole saliva (2), parotid saliva (3) and submandibular-sublingual saliva (4) of BMS patients (in grey) and healthy controls (in black). Table s1. Elution times, experimental and theoretical average Mass values, and m/z multiply charged ions used for XIC search, of cystatins, histatins, α-defensins and some derivatives. Table s2. Elution times, experimental and theoretical average Mass Values, and m/z multiply charged ions used for XIC search, of salivary acidic and basic proline-rich proteins, statherin, P-B peptide and derivatives.

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