This dataset contains the hydrographic data for all the stations conducted during the EUROFLEETS+ SINES cruise that took place aboard the R/V Sarmiento de Gamboa between 11-20th of September 2022.  The project "Climate change impact on ocean fronts ecosystems: The case of the Iberian Upwelling System (SINES)" was planned to be a proof of concept cruise of multidisciplinary research: integrating satellite data to past sediment records within classical methods in oceanography research and automated underwater vehicles to tackle the characterization of the Iberian Margin Upwelling System. The overall objective of this study is to identify the changes and risks for marine ecosystem services deriving from the potential impact of climate change on upwelling fronts. This research cruise was funded by the Eurofleets+ SEA Programme Call “REGIONAL” in 2019/2020 and was led by the Centre of Marine Sciences of Algarve (CCMAR, Portugal). The proposed multidisciplinary expedition was carried out between 11-19th September 2022. Full depth water column CTD profiles were collected at all the stations (15 stations, 19 CTD casts, i.e, four stations with double cast -shallow and deep-). In 12 stations, a vertical multinet haul was also collected. The depth of the multinet samples (100 µm mesh) range between 700 m and surface. A deployment of a Light Autonomous Underwater Vehicle (LAUV Explore-4) was done on 17-18th of September. The AUV conducted more than 100 high-resolution immersion profiles between the surface and 10/50/100 m depth following the track of the research vessel between the coast and the position 37.35ºN 9.4ºW. This repository included also remote sensing data from satellite observations and the processed hull mounted Acoustic Doppler Current Profiler (ADCP) data. Complete list of stations, events and positions of EUROFLEETS+ SINES also available in the dataset.