How does oxidative damage change peptide membrane insertion?

DOI

The insertion of peptides and proteins into cell membranes is crucial for the functioning of cells, and also for the functioning of a variety of antibacterial reagents. Cells are continually subject to oxidation events. In this experiment we will use neutron reflection to investigate how oxidative damage changes the interaction between two different, well studied peptides, melittin and protegrin, and cell membrane models of differing composition. The results will help us understand better the factors that influence the interaction of different peptides with cell membranes, and how that interaction is changed by oxidative damage.

Identifier
DOI https://doi.org/10.5286/ISIS.E.94114868
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/94114868
Provenance
Creator Mr Emil Gustafsson; Professor Adrian Rennie; Dr Katherine Thompson; Dr Mario Campana
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2018-07-08T08:00:00Z
Temporal Coverage End 2018-09-18T13:53:03Z