This dataset was collected to examine whether adolescents who experiment with e-cigarettes have an increased chance to start using tobacco. However, we measured use of alcohol and other drugs as well, delinquent behavior, and personality characteristics. The longitudinal design included baseline (N=2,839) and 6- (N=1,276) and 12-month (N=1,025) follow-up surveys among a school-based cohort (mean age: 13.62). Ten high schools were recruited as a convenience sample.