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Ligand induced changes of the 18kDa translocator protein in a lipid bilayer
The proposed experiments will investigate conformational changes of the 18kDa translocator protein (TSPO) in a lipid bilayer using neutron reflectometry at the solid-liquid... -
Interfacial properties of a lung protein after exposure to gas-phase ozone
Lung surfactant protein B, SP-B, is found at the air-water interface of the lung. A deficiency in SP-B at birth is known to be fatal. We have recently successfully studied the... -
Nature of the protein corona on nanoparticle surfaces
When nanoparticles enter a biosytem they rapidly acquire a protein corona. The nature of the outer part of this corona will determine the response of the biosystem to the... -
Oriented antibody binding layers
The proposal concerns the assembly of high density antibody binding surfaces to increase the sensitivity of medical diagnostics. Previously we showed that antibody binding... -
A study of protein adsorption via chelating lipids within a solid supported l...
The crystallisation of membrane proteins is of great interest, not least, to the pharmaceutical industry. We have recently begun a project aiming to investigate the role played... -
Further SANS contrast measurements on important protein/DNA interactions from...
This proposal is to perform further SANS contrast measurements on three protein/DNA interactions currently worked on at the Research Complex at Harwell. This is part of an... -
Neutron scattering study on dynamics of cytochrome c in MCM41
Studies of internal dynamics in the pico seconds timescale, of cyt c trapped in MCM-41, would allow the forms, geometry, amplitudes and time-dependence of the motions involved... -
Characterisation of bioadhesive protein-PEG conjugates grafted to titanium su...
Summary: Titanium implants are surgically important and require a hydrophilic polymer coating to prevent biofouling in situ. Bioadhesive proteins can be covalently tethered to... -
Supramolecular assemblies of arginine and their impact on protein aggregation
Arginine is an important molecule which utilised in industrial, biochemical and medical research to aid in the successful refolding of proteins and to resist the effects of... -
Conformational change of glycerol faciliitator protein on substrate binding
A large family of membrane channel proteins selective for transport of water (aquaporins) or water plus glycerol (aquaglyceroporins) has been found in diverse life forms. E.... -
Understanding the true biological function of Plant Non Specific Lipid Transf...
Non specific lipid transfer proteins are a family of basic, cysteine rich proteins found in a wide range of plant species. The biotechnological role of these proteins in beer... -
Solution Structure of the OmpF-TolA complex
Gram negative bacteria cause a wide range of diseases including meningitis, bubonic plague, gonorrhoea, diarrhoea, Legionnaires' disease and cholera. Their outer membrane... -
Dynamics of trehalose-glycerol and lysozyme/trehalose-glycerol mixtures
The proposed experiment aims to study the dynamics of trehalose/glycerol mixtures and lysozyme in presence of trehalose/glycerol mixtures at different relative concentration.... -
OB Buffer - 40% D2O_SANS
This dataset has no description
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Further SANS contrast measurements on important protein/DNA interactions from...
This proposal is to perform further SANS contrast measurements on three protein/DNA interactions currently worked on at the Research Complex at Harwell. This is part of an... -
How do colloidal nanocrystals appear to biological systems? A SANS study of t...
A key aspect of any biological application of nanomaterials is to understand what happens when they are introduced into biological environments. When particles are introduced... -
Solution structures of three immunologically important proteins IgA, C3 and IgG
Abnormally glycosylated IgA leads to IgA nephropathy, the most common cause of renal failure. IgG antibody represents one-third of new drugs currently in development, and its... -
Structural Study of Functional Nucleosome in Solution
Recently, it is reported that the functional nucleosomes, CENP-A nucleosome, H2A.Bbd nucleosome and hexasome, which include variant histone cores, could have flexible and mobile... -
Dynamics of amyloid protein fibril growth using isotope-labelled SANS
This proposal aims use a novel approach whereby deuterated amyloid peptide fibrils are givenhydrogenated growing ends, and analysed using SANS. The data will enable us to... -
Organisation of Outer membrane protein F at the air/liquid interface
Crystallisation of membrane proteins as a precursor to high resolution structural studies is a significant research bottleneck. We are investigating alternative methods to...
