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Probing the internal structure of gene delivery vehicles using contrast varia...
Gene delivery vehicles, known as LPD complexes, prepared from mixing cationic lipid vesicles (L) with cationic peptide (P) and DNA (D) have proven to be very effective at... -
Neutron Reflectivity Study of Antimicrobial Peptides Interacting with Lipopol...
The outer membrane (OM) of gram negative bacteria is mainly constituted of highly polydisperse and amphiphilic lipopolysaccharide (LPS), an endotoxin which is accompanied by... -
Antimicrobial Peptide Binding & Rearrangement in Model Membranes ¿ Building a...
Antimicrobial peptides (AMPs) are attractive drug candidates because of their selectivity and speed of action against bacteria. We have developed a novel approach to delivering... -
The Orientation and Conformation of Synthetic 3-10 Helical Peptides within Su...
This dataset has no description
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NR Study of Selective Binding of a-Helix Antimicrobial Peptides onto Bacteria...
In this work we will explore how to use PolRef to study the binding of our rationally designed peptide amphiphiles onto floating lipid bilayers mimicking G- bacterial and red... -
Structure of siRNA containing delivery vehicles: effect of serum
Complexes prepared from cationic, dichain lipid (L) vesicles and negatively charged siRNA (R), with and without positively chargely targeting peptides (P) known as LR or LPR... -
Interfacial layer structure of peptide surfactants: the effect of hydrophobic...
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation.... -
Structure of aggregation of peptide surfactants: effect of the size of amino ...
Peptide surfactants are a group of interesting biomimetic amphiphiles capable of forming a range of nanostructures. The aim of this work is to use SANS to determine the... -
Lipopolysaccharide-antimicrobial peptide complexes in solution:elucidation of...
Lipopolysaccharide or endotoxin (LPS) is an amphiphilic macromolecule which constitutes the outer membrane of gram negative bacteria.During infection, LPS is released from the... -
Interaction of keratin with surfactants studied by neutron reflection
This proposal constitutes part of our ongoing study towards understanding how keratin, an important protein component of hair and skin, interacts with ionic surfactants using... -
Solution aggregation of short peptide surfactants
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation.... -
Insertion of antimicrobial peptides into phospholipid monolayers at air/liqui...
We have designed a series of cationic peptides with different helix repeats that can kill bacteria but remain benign to mammalian host cells. The selectivity to cell types is... -
Solution Aggregation of Short Peptide Amphiphiles
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly, leading interfacial adsorption and solution nano-aggregation.... -
Using SERGIS to characterise monolayer buckling on the approach to collapse
Thin films just one or a few molecules thick can play an important role in controlling many important phenomena. This includes the lipid monolayers that coat the surface of our... -
Investigation of the structure of self-assembling peptide fibrils using neutr...
A consortium of several UK universities and industries has been set up, based at the National Physical Laboratory, Teddington, to investigate ¿Length-scale bridging in... -
A SANS Study on the Influence of Shear on Peptide Fibrillisation
Time-resolved SANS will be performed to investigate the effect of shear on the fibrillisation of insulin following denaturation. The rheological response will be measured... -
Intermediate Structures formed during the aggregation of the Amyloid beta Pep...
The aggregation of the Amyloid beta (Abeta) peptide is implicated in the progression of Alzheimer's disease, the treatment of which is a major current global healthcare... -
Rheo-SANS study of peptide gels
Low molecular weight gelators (LMWG) form hydrogels via self-assembly in water under specific conditions to form long, fibrillar structures. Non-covalent forces interactions... -
Self-assembly of detergent molecules below ambient temperature: SANS to deter...
Although surfactant detergency is well understood above 30 C, actions of surfactants below 30 C are not well established. In the era of energy saving and environment caring, we... -
Structural study on the 3D arrangement of (hexa-acyl) lipid A in lipid membrane
This study will focus on the structural investigations of the bilayers formed on silicon substrates in which the outer leaf consists of DOPE/LPS mixtures. We aim is to achieve...
