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Structural study on the 3D arrangement of (hexa-acyl) lipid A in lipid membrane
Lipopolysaccharides are amphiphilic macromolecules indispensable for the growth and the survival of Gram-negative bacteria, one of the most diffuse classes of pathogenic... -
Conformation of di-stearoyl-polyethylene glycol surfactants as enhancers of b...
This proposal relates to the structural studies of Di-stearoyl and di-palmitoyl Polyethylene glycol derivates as a function of the PEG head group at the air-water and the... -
Realistic bacterial membrane mimetics to understand antimicrobial activity & ...
We will use neutron reflectivity measurements of lipopolysaccharide (LPS) layers at the air-water interface to help develop a realistic mimetic for the periphery of bacteria... -
Hydrogen diffusion in Palladium-Silver membranes measured by QENS
Hydrogen selective membranes based on palladium are important for technological processes such as isotopic separation and gas purification.In general, a Pd membrane when... -
Conformational analysis of subtilin / lipid II binary antibiotic/target membr...
Antibiotic resistance is pathogenic bacteria is a major clinical problem. Resistance to all antibiotiotic classes, currentl yin clinical use, has been reported. By contrast, the... -
Calcium mediated interaction between siRNA and phospholipid bilayers: the eff...
The main objective of the present study is to gain an understanding of the nature of the interaction of ¿phospholipid membranes¿ with small, interfering RNA (siRNA) in the... -
Molecular interactions between phospholipid monolayers and dimethylsulphoxide
Neutron reflectivity will be employed to investigate the interaction between dimethylsulphoxide and monomolecular films of phosphatidylcholine. The monolayer will be used as a... -
Probing membrane localisation of molecular rotors (SANS)
A number of important biological processes, such as intracellular transport and signal transduction depend on the viscosity and the distribution of microdomains in cells. We... -
Conformational changes on interaction of cytochrome c with lipid monolayers.
The main objective of the present work is to gain an understanding of the interaction of the cationic protein, cyt c with anionic lipid membranes. This objective will be... -
Hydrogen diffusion at hight temperature and pressure in palladium-silver memb...
Hydrogen selective membranes based on palladium are very important for technological processes such as isotopic separation and gas purification. As a matter of fact, both... -
The structure of ceramides in a model membrane environment
This proposal aims to investigate the structure of ceramide, an important component of cellular membranes in a mimic membrane environment. After assessment of this molecule in... -
Characterising the membrane binding interaction of plant annexin Gh1
Annexins are a ubiquitous group of membrane associated proteins found in animals, plants and fungi. They are linked to wide range of functions including phospholipid... -
Binding of DNA to Model Membranes in the Presence of Ca2+ Ions and a Membrane...
The aim of the present work is to gain an understanding of the interaction of DNA with the phospholipid bilayers. The effect of different forms of DNA, the presence of divalent... -
Comparison Phase-object approximation and dynamical scattering theory
X-ray, electron and neutron scattering techniques have been used for the structural characterization of surfaces and embedded morphologies. Several theories have been developed... -
Structural study on the 3D arrangement of (hexa-acyl) lipid A in lipid membrane
This study will focus on the structural investigations of the bilayers formed on silicon substrates in which the outer leaf consists of DOPE/LPS mixtures. We aim is to achieve... -
Probing membrane localisation of molecular rotors
A number of important biological processes, such as intracellular transport and signal transduction depend on the viscosity and the distribution of microdomains in cells. We... -
The effect of membrane fluidity on the interaction of antimicrobial proteins ...
Protein-lipid\membrane interactions are fundamentally important to biological processes. We have examined the role protein hydrophobicity in protein-membrane interactions... -
Probing membrane localisation of molecular rotors
A number of important biological processes, such as intracellular transport and signal transduction depend on the viscosity and the distribution of microdomains in cells. We... -
Determining the membrane binding structure of drug-delivery polymers
This proposal seeks to investigate a class of synthetic membrane-active biopolymers which have been developed as potential drug-delivery agents. These polymers have shown pH-... -
Poster - Regulation of Podoplanin Expression and Function
Poster presented by Dr Lotte de Winde at #EMBOmesenchymalcells Athens May 2019Poster - Regulation of Podoplanin Expression and Function