146 datasets found

The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents. The successful development of...

Proteasome plays an important role in the processing of antigenenic proteins for presentation by the MHC class I pathway. PA28 is an activator of the 20S proteasome, a large...

We have developed an experimental approach using a buried magnetic layer to provide contrast in systems consisting of complex biomolecular layers tethered to gold surfaces. This...

The aim of this proposal is to determine the thickness of a water layer surrounding colloidal particles dispersed in oil with changes in ionic strength. Recent work by our group...

Replication protein A (RPA), the eukaryotic ssDNA binding protein, is a heterotrimeric protein required for almost all aspects of cellular DNA metabolism. RPA binds...

This proposal is part of a broad programme of collaborative research between RAL / Oxford and Unilever, using predominantly scattering techniques to investigate the nature of...

Small aromatic compounds are strongly solubilised by Pluronic block copolymers. This includes adjuvants, which are compounds used in the pharmaceutical industry to aid drug...

Cubosomes and hexosomes are particles with internal liquid crystal structures of the bicontinuous cubic or reverse hexagonal nanostructures respectively. The nanostructure...

Incorporation of d- or f-block metals into ligand systems that renders a metal complex surface active or drives its partitioning into surfactant phases enables the localisation...

In this proposal we wish to continue our current work on mesostructured inorganic films in largely ethanolic solutions, containing limited amounts of water. Transition metal...

The puroindoline (PIN) and purothionin (PTH) families of polypeptides both occur in wheat and are implicated in antipathogenic defence mechanisms, and of interest for potential...

Antibiotic resistance is pathogenic bacteria is a major clinical problem. Resistance to all antibiotiotic classes, currentl yin clinical use, has been reported. By contrast, the...

Inelastic neutron scattering has proven to be reliable tool to investigate the phonon structure of hydrides. E.g., it was shown that the vibrational structure of Ca(BH4)2 has a...

Phenomena surrounding the wetting of natural or artificial topographically patterned surfaces are found systems associated with the diverse fields of chemical engineering,...

We wish to investigate the magnetic structure of a series of magnetic multilayers using a new technique we have successfully implemented called Spin Echo Modulated Small Angle...

Complexes prepared from cationic, dichain lipid (L) vesicles and negatively charged siRNA (R), with and without positively chargely targeting peptides (P) known as LR or LPR...

The proteins of the outer membrane of Gram-negative bacteria are critical for bacterial survival, from providing basic physiological functions, to impairing virulence and...

Ferromagnetic shape memory alloys can undergo reversible strain changes in external magnetic fields. Here we want to characterize NiMnGa alloys, which present brittle behavior...

The anti-fungal agent amphotericin B (AmB) can be administered to patients in aqueous solution complexed with cholesteryl sulfate (CS), and this formulation helps to minimise...

Incorporation of d- or f-block metals into ligand systems that renders a metal complex surface active or drives its partitioning into surfactant phases enables the localisation...