47 datasets found

The proteins of the outer membrane of Gram-negative bacteria are critical for bacterial survival. The understanding of how these proteins are targeted and folded into this...

We have a programme investigating the structure and function of protein scaffolds oriented on gold surfaces using sulfur chemistry for attachment. The aim is to direct the...

We propose to collect, on TOSCA, the IINS spectrum of the [(Ph3P)2N] [HCo6(CO)15] complex to obtain information on the dynamics of the interstitial hydride and the influence, on...

Gene (nucleic acid) delivery to the cytosol or nucleus of a cell is, without the aid of a suitable delivery system, an inefficient process. Here the interaction of a defined...

This proposal is part of our research programme on spin and orbital order in frustrated systems. AgNiO2 has a layered crystal structure with Jahn-Teller active Ni3+ ions forming...

This proposal is part of our research programme on spin and orbital order in frustrated systems. AgNiO2 has a layered crystal structure with Jahn-Teller active Ni3+ ions forming...

The study of novel manganites, where the tailoring of the Mn formal valence state on the B site is done by the ordering of different cations on the A site of the ABO3 (B:Mn)...

Hydrogen chloride exhibits a complex phase diagram account made of its simple molecular structure. Three crystalline phases are known to exist at ambient pressure below its...

Neutron scattering is a powerful technique to study stochastic motions in liquids but it requires an energy resolution well below the meV range. As a consequence, quasielastic...

The reaction of LiH with the oxy-chloride Sr3Fe2O5Cl2 initially leads to the topotactic deintercalation of oxide ions and the formation of Sr3Fe2O4Cl2 containing sheets of...

When nanoparticles enter a biosytem they rapidly acquire a protein corona. The nature of the outer part of this corona will determine the response of the biosystem to the...

As part of our program in understanding hydrogen bonding systems, exploiting crystal engineering in our synthesis of complexes containing desired HB motifs, we investigate...

Gram negative bacteria cause a wide range of diseases including meningitis, bubonic plague, gonorrhoea, diarrhoea, Legionnaires' disease and cholera. Their outer membrane...

Large multiprotein complexes are the new frontier in structural biology. Individual proteins may be solved by X-ray crystallography but the relationships between subunits and...

Complexation is of interest in pharmaceutical field, since it increases solubility and bioavailabilityof drugs. We want to perform a inelastic neutron scattering (INS) study,...

Progress in the development of nano-sized hybrid therapeutics and nano-sized drug delivery systems - "nanomedicines" - over the last decade has been remarkable. One key...

We propose to look at the interaction of the aggregates two phospholipids form with two phospholipase (PL) enzymes, PLA2 and PLC, which hydrolyse different ester groups in the...

We have previously solved the structure by SANS of the complex between the outer membrane protein F of E coi and the toxin colicin N which is a large antibiotic protein. This...

We have previously studied proteins with IINS, as well as their building blocks (20 different amino acids). The latter studies of amino acids yielded sharp vibrational peaks...

In recent incoherent inelastic neutron scattering experiments we have shown that the anharmonic single-particle dynamics of H2 can be measured with high precision in quantum...