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Structural stability of novel anticancer hexameric fusion protein: SANS inves...
A shift towards antibody-based cancer treatments has occurred due to their ability to provide targeted cancer treatment with fewer negative side effects than traditional... -
Dynamics of amyloid protein fibril growth using isotope-labelled SANS
This proposal aims use a novel approach whereby deuterated amyloid peptide fibrils are givenhydrogenated growing ends, and analysed using SANS. The data will enable us to... -
SANS investigation of proteins trapped in hydrogels formed by binary mixtures...
Aqueous solutions of guanosine 5-monophosphate (GMP) can turn into isotropic gels by the addition of guanine (Gua). The Gua:GMP hydrogel property of including a significant... -
Structural Control of Microemulsion Droplets by Multiple-bridging Amphiphilic...
Microemulsions are thermodynamically stable, low-viscous liquid mixtures of oil and water stabilised by the presence of surfactant, structurally composed of oil-in-water (O/W)... -
Kinetics of the formation of eumelanin and its intermediates
The proposed research project is targeted to the investigation of the characteristics of eumelanin, a heterogeneous material insoluble in water and in any organic solvent, as... -
Composite Electrospun Fibres based on Food waste
Thus proposal seeks to explore the nature of electrospun composite fibres where the polymeric material contains a substantial quantity of biopolymer obtained from food waste -... -
An Investigation of Interfacial Structure of Pluronics at Solid-Liquid Interf...
Tri-block copolymers offer an excellent model system for the study of crystallization in the bulk as well as close to interfaces. It is known that the structures formed by this... -
Interactions of Cationic Surfactants with Phospholipid Vesicles: Influence of...
Surfactants are frequently used in personal care products to improve the wetting and oil solubilizing qualities of the products, which also leads to the skin irritation by... -
Formulating polymer solutions to stabilise polymeric foams
Polyurethane foams (PUF) are commonly prepared by mixing Pluronic type copolymers and isocyanate reactive monomers in the presence of additives e.g. catalysts, blowing agents... -
Using SANS2D to resolve the opening of MscL clusters in proteoliposomes in re...
In bacteria, mechanosensitive ion channels such as MscL protect cells against osmotic shock. Although crucial for protecting cells, as with all ion channels, they have the... -
Solution structures of the immunologically important proteins IgA, IgG and C3
Abnormally glycosylated IgA leads to IgA nephropathy, the most common cause of renal failure. IgG antibody represents one-third of new drugs currently in development, and its... -
Architecture of lipid-protein nanoglobules in velvet worm prey capture slime
Fiber fabrication in animals is an important inspiration source for polymeric materials. Velvet worm prey capture slime represents a unique way of fiber fabrication by using... -
SANS Studies of Nanostructures of Microfluidically Fabricated lipid Nanoparti...
We have developed a new approach for forming lipid nanoparticles (LNP) with and without interfering RNA and DNA from a microfluidic setup. The LNPs are formed by an ionisable... -
Opening up microemulsion phases in CO2
New types of water-in-CO2 microemulsions using mixed surfactant systems will be investigated by high-pressure SANS (HP-SANS). Exciting new results (see report on RB820030) have... -
Developing a general approach to resolution of accessory proteins bound to cl...
Endocytosis plays a central role in allowing the selective transport of molecules, via membrane-derived vesicles, into cells. Vesicle formation is controlled by a complex... -
Micellization in H/F-Carbon surfactant mixtures used in fire-fighting foams
The aim is to probe the micellar compositions of fluorocarbon/ hydrocarbon mixtures used in commercial fire-fighting foam formulations (Figure 1) using contrast variation SANS.... -
Development of Creep Cavitation in Stainless Steel
Reheat cracking is a creep failure mode that has been observed in welded structures operating at high temperatures in the power generation industry. The failure results from the... -
Using SANS to understand the structural basis for the rheology of molten choc...
Molten chocolate is a semi-solid suspension of (mostly) sugar, but also cocoa and milk solids in oil. In order to allow the sugar grains to flow past each other, either when the... -
Magnetic nanostructures of Fe-Ag and Fe-Au granular thin films
Nanogranular thin films of FexM100-x (M=Au,Ag; x=7,20,39) are an excellent system to study the magnetism of nanoparticles in diamagnetic matrices coupled by direct, RKKY and... -
Quad-chain surfactants for CO2
In recent years much progress has been made in the design of surfactants that are soluble in liquid CO2; hence these additives able to modify physicochemical properties...