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interaction of a pharmaceutical water-soluble polymer with bio-relevant surfa...
We have been developing hydroxypropylmethyl cellulose (HPMC) microspheres for delivering poorly water-soluble drugs. The in vitro dissolution data showed that the presence of... -
Rheo-SANS of folded maltose binding protein hydrogels
Hydrogels are formed by the self-assembly of cross-linked building blocks in water.By using a folded protein as the building block, we wish to harness the intrinsic and specific... -
Protein-decorated superparamagnetic iron oxide nanoparticles
The aim of this research is to understand the structural confirmation of dextran coated iron oxide (Fe3O4) nanoparticles in the presence of Bovine serum albumin (BSA) in aqueous... -
Kinetic Study of the Mechanistic Complexation Process Between DNA and Cationi...
We propose to use the new SANS2d to study the dynamic structural evolution in the couse of the formation of DNA-cationic polymer complexes. The dynamic process and the mixing... -
Dynamical process of helical-biskyrmion transformation of hexagonal magnet Mn...
Magnetic skyrmions are vortex-like, magnetic-spin objects that were lately discovered in bulk chiral magnetic materials. Recently, we discovered super stable magnetic... -
Micelle structures in unequal mixtures of amino-acid surfactants
In a previous proposal we started to study the micellar structures formed from biodegradable surfactants synthesised using amino acids as the headgroups. The aim of this work is... -
Exchange kinetics of complex coacervates core micelles
Coacervates have been studied for a long time for their unusual properties: they are dense networks of charged polymers that are soluble in water. Instead of flocculating when... -
SANS study of formation of gels and foams from gelatin with metal salts
Recently, we have prepared highly active carbon catalysts for the oxygen reduction reaction in hydrogen fuel cells. These materials are synthesized easily by mixing metal... -
A SANS study of nano-gels with a temperature tunable bio-interface
Hyaluronic acid (HA) plays a key role in tumour cell bio-adhesion and, as such, this interaction opens up possibilities for targeted tumour pathologies We have created a... -
Investigating Nano-segregation and Structuring in Ionic Liquid Mixtures using...
It is proposed to use small-angle neutron scattering (SANS) to investigate in detail the binary phase diagram between 1-ethyl-3-methylimidazolium... -
SANS Investigation into the Mode of Interaction between Antibiotics and Diffe...
In this part of proposed work, we wish to explore how antibiotics minocycline and tetracycline interact with model lipid bilayers in the form of SUVs, mimicking key features of... -
Compartmentalised Supramolecular Structures through CB[8]-mediated Hierarchic...
We have recently developed a method to prepare a wide variety of amphiphilic diblock copolymers through a supramolecular linkage that is stable in water. This has been achieved... -
Small-Angle Neutron Scattering studies of a bacterial colonization factor
We plan to carry out SANS experiments on a bacterial colonization factor to elucidate how it interacts with chitin, which is found on the surface of plankton and crustaceans.... -
Quantitative analysis of precipitate coarsening in V and V-Mo microalloyed steel
Ever-more stringent environmental regulations have driven the automotive industry to continuously develop lightweight solutions in automotive body sheet materials, without... -
Use of nitric oxide radicals for the formation of a supramolecular hydrogel
The aim of this proposal is to study the structure of hydrogel systems formed from fluorenylmethyloxycarbonyl (FMOC) protected peptides, via the use of nitric oxide radicals.... -
Surfactant induced gelation of TEMPO-oxidized cellulose; Using betaine-based ...
Our group has been working cellulose nanofibrils (OCNF) which form hydrogels in the presence of certain additives. Previously, we have studied the effect of salt, single... -
Lipid exchange dynamics between native lipoprotein particles and human cell m...
Atherosclerosis is the primary cause of death in westernized societies. Clinical indicators include not only the net lipoprotein concentration but also the ratio between the... -
Structural Control of Microemulsion Droplets by Multiple-bridging Amphiphilic...
Microemulsions are thermodynamically stable, low-viscous liquid mixtures of oil and water stabilised by the presence of surfactant, structurally composed of oil-in-water (O/W)... -
Micelle structures in mixtures of amino-acid surfactants
There has been a recent revival of interest in preparation of surfactants from natural starting materials as they are more biodegradable and thus more environmentally friendly... -
Probing the effect of hydrophobic end chain length on the interaction of hydr...
Polymers are used to increase the viscosity of formulations to impart beneficial characteristics. To minimize the amount of polymer needed, polymers that form gels through...
