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Self-assembly of lipid and triblock copolymer-based amphiphiles for drug deli...
Soft self-assembled structures have been extensively used as drug nanocarriers. Their building blocks, naturally occurring and synthetic amphiphiles (lipids or block... -
Exchange kinetics of telechelic Cn-PEO-Cn micelles: effect of conformation an...
The microscopic dynamics of associative polymers that self-assemble into micellar structures play a key role for their macroscopical properties, with important implications for... -
Effect of emulsifier and added preservative on the structure and stability of...
Investigations will be performed to determine the effect of composition on the internal structure of semi-solid oil-in-water emulsions designed to model the GlaxoSmithKline... -
Partially deuterated gradient poly(2-oxazolines): self-assembly studies
Gradient and block copoly(2-oxazoline)s have been prepared comprising a partially deuterated hydrophilic poly(2-methyl-2-oxazoline) part and a hydrogenated... -
Perfluorocarbon-loaded polymeric nanoparticles with multiple perfluorocarbon ...
Ultrasound is a very attractive and patient-friendly imaging technique, as it is easy to use, fast and non-invasive. Nevertheless, its use is severely limited by the low... -
How aggregate lifetimes affect the kinetics of surfactant surface multilayer ...
The spontaneous formation of multilayer structures at interfaces from surfactant self-assembly is an important structural signature associated with a wide range of technological... -
Concentrated emulsions as proxy CO2 thickeners
The proposal aims to explore the oil-in-water (brine) high internal phase emulsion systems (HIPEs) formed by nonylphenol ethoxylate surfactants using contrast variation SANS... -
Cationic surfactant self-assembly in choline chloride:malonic acid deep eutec...
Deep Eutectic Solvents (DES) are mixtures of organic salts and hydrogen bond donors, that form strongly hydrogen-bonded room temperature ionic liquids (ILs). DES share many... -
A Time-Resolved SANS Study of the Gelation Mechanisms of Tetrapeptide Hydroge...
Time-resolved SANS will be used to investigate the mechanisms and kinetics of ordering of aseries of novel designed tetrapeptide-based hydrogelators. These inexpensive materials... -
SANS from photoconductive hydrogel mixtures and their gelators.
Hydrogels are formed from a self?assembled network of fibres made up of small molecules (gelators) trap and hold water at just 1% by weight, or less, from the solution they are... -
Micelle Formation in Lanthanide-Based DES
Deep eutectic solvents (DES) share many features with ionic liquids (ie. tunable physicochemical properties) which makes them viable green solvents that are less toxic than... -
SANS studies of Physiogel creams
Aqueous creams are widely used to treat skin conditions like rosacea, dermatitis and psoriasis.They are very complex chemical mixtures, and our knowledge of their molecular... -
Solventless protein liquids: a novel form of biological matter
Solventless protein liquids (SPLS) represent a novel form of biological matter. Recently we reported on the preparation and properties of a solvent-free liquid protein based on... -
interaction of a pharmaceutical water-soluble polymer with bio-relevant surfa...
We have been developing hydroxypropylmethyl cellulose (HPMC) microspheres for delivering poorly water-soluble drugs. The in vitro dissolution data showed that the presence of... -
Rheo-SANS of folded maltose binding protein hydrogels
Hydrogels are formed by the self-assembly of cross-linked building blocks in water.By using a folded protein as the building block, we wish to harness the intrinsic and specific... -
Protein-decorated superparamagnetic iron oxide nanoparticles
The aim of this research is to understand the structural confirmation of dextran coated iron oxide (Fe3O4) nanoparticles in the presence of Bovine serum albumin (BSA) in aqueous... -
Kinetic Study of the Mechanistic Complexation Process Between DNA and Cationi...
We propose to use the new SANS2d to study the dynamic structural evolution in the couse of the formation of DNA-cationic polymer complexes. The dynamic process and the mixing... -
Dynamical process of helical-biskyrmion transformation of hexagonal magnet Mn...
Magnetic skyrmions are vortex-like, magnetic-spin objects that were lately discovered in bulk chiral magnetic materials. Recently, we discovered super stable magnetic... -
SANS Investigation into the Mode of Interaction between Antibiotics and Diffe...
In this part of proposed work, we wish to explore how antibiotics minocycline and tetracycline interact with model lipid bilayers in the form of SUVs, mimicking key features of... -
SANS Studies of Radiation-grafted Anion-exchange Membranes with Different Gra...
We request one days beam time on SANS2D for the study of hydrated, radiation-grafted anion-exchange membranes synthesised with different grafting times. These materials are...